{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["21(6)"],"submitter":["Huang Y"],"pubmed_abstract":["<i>Carpesium cernuum</i> L. is a traditional medicine primarily used in Southwestern China, and it has been shown to exhibit a range of biological properties, including anti-inflammatory and antitumor activities. Incaspitolide A (IA) is a sesquiterpene isolated from <i>C. cernuum</i> L. The aim of the present study was to investigate the antiproliferative effects of IA on PC-3 prostate cancer cells and determine the underlying mechanism. Results from a Cell Counting Kit-8 assay demonstrated that IA significantly reduced the numbers of viable PC-3 cells in a time and dose-dependent manner. Phase-contrast microscopy revealed that the number and morphology of cells were markedly altered. Hoechst and EdU staining assays showed that IA reduced the proliferation of PC-3 cells. Flow cytometry ana"],"journal":["Oncology letters"],"pagination":["477"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC8100957"],"repository":["biostudies-literature"],"pubmed_title":["Incaspitolide A isolated from <i>Carpesium cernuum</i> L. inhibits the growth of prostate cancer cells and induces apoptosis via regulation of the PI3K/Akt/xIAP pathway."],"pmcid":["PMC8100957"],"pubmed_authors":["Huang Y","Guo H","Chen M","Yan C","Zhang L","Mao J"],"additional_accession":[]},"is_claimable":false,"name":"Incaspitolide A isolated from <i>Carpesium cernuum</i> L. inhibits the growth of prostate cancer cells and induces apoptosis via regulation of the PI3K/Akt/xIAP pathway.","description":"<i>Carpesium cernuum</i> L. is a traditional medicine primarily used in Southwestern China, and it has been shown to exhibit a range of biological properties, including anti-inflammatory and antitumor activities. Incaspitolide A (IA) is a sesquiterpene isolated from <i>C. cernuum</i> L. The aim of the present study was to investigate the antiproliferative effects of IA on PC-3 prostate cancer cells and determine the underlying mechanism. Results from a Cell Counting Kit-8 assay demonstrated that IA significantly reduced the numbers of viable PC-3 cells in a time and dose-dependent manner. Phase-contrast microscopy revealed that the number and morphology of cells were markedly altered. Hoechst and EdU staining assays showed that IA reduced the proliferation of PC-3 cells. Flow cytometry ana","dates":{"release":"2021-01-01T00:00:00Z","publication":"2021 Jun","modification":"2025-04-21T18:22:16.52Z","creation":"2025-04-05T17:13:03.748Z"},"accession":"S-EPMC8100957","cross_references":{"pubmed":["33968193"],"doi":["10.3892/ol.2021.12738"]}}