{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Wilkie H"],"funding":["National Institute of Allergy and Infectious Diseases","NIAID NIH HHS","National Institutes of Health"],"pagination":["1503-1511.e3"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC8102650"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["141(6)"],"pubmed_abstract":["Chronic dermatitis is a hallmark of Dedicator of cytokinesis 8 (DOCK8) deficiency. The migration of DOCK8-deficient T cells to the skin and their survival there have been reported to be defective. Surprisingly, we found that Dock8<sup>-/-</sup> mice demonstrated an exaggerated contact hypersensitivity (CHS) response to oxazolone with increased ear swelling, T-cell infiltration, and expression of Ifng. To understand the mechanisms of persistent skin inflammation in DOCK8 deficiency, we examined mice with selective deficiency of DOCK8 in T cells or T regulatory cells (Tregs) and found that both have exaggerated CHS. Moreover, oral tolerance to oxazolone, mediated by Tregs, was impaired in Dock8<sup>-/-</sup> mice. Transfer of Tregs from oxazolone-sensitized wild-type mice, but not Dock8<sup>"],"journal":["The Journal of investigative dermatology"],"pubmed_title":["DOCK8 Expression in Regulatory T Cells Maintains their Stability and Limits Contact Hypersensitivity."],"pmcid":["PMC8102650"],"funding_grant_id":["R01 AI153257","USPHS RO1AI114588","K08AI114968","R01 AI100315","K08 AI114968","T32 AI007512","5T32AI007512"],"pubmed_authors":["Geha RS","Wilkie H","Leyva-Castillo JM","Janssen E"],"additional_accession":[]},"is_claimable":false,"name":"DOCK8 Expression in Regulatory T Cells Maintains their Stability and Limits Contact Hypersensitivity.","description":"Chronic dermatitis is a hallmark of Dedicator of cytokinesis 8 (DOCK8) deficiency. The migration of DOCK8-deficient T cells to the skin and their survival there have been reported to be defective. Surprisingly, we found that Dock8<sup>-/-</sup> mice demonstrated an exaggerated contact hypersensitivity (CHS) response to oxazolone with increased ear swelling, T-cell infiltration, and expression of Ifng. To understand the mechanisms of persistent skin inflammation in DOCK8 deficiency, we examined mice with selective deficiency of DOCK8 in T cells or T regulatory cells (Tregs) and found that both have exaggerated CHS. Moreover, oral tolerance to oxazolone, mediated by Tregs, was impaired in Dock8<sup>-/-</sup> mice. Transfer of Tregs from oxazolone-sensitized wild-type mice, but not Dock8<sup>","dates":{"release":"2021-01-01T00:00:00Z","publication":"2021 Jun","modification":"2025-04-29T11:29:24.571Z","creation":"2025-04-29T11:29:24.571Z"},"accession":"S-EPMC8102650","cross_references":{"pubmed":["33171169"],"doi":["10.1016/j.jid.2020.09.027"]}}