biostudies-literatureCarmen-Orozco RPNIAID NIH HHSFIC NIH HHSCienciactiva PeruInnóvate PerúNational Institutes of Healthe0009295https://www.ebi.ac.uk/biostudies/studies/S-EPMC8104410biostudies-literatureUnknown15(4)<h4>Background</h4>The parasite Taenia solium causes neurocysticercosis (NCC) in humans and is a common cause of adult-onset epilepsy in the developing world. Hippocampal atrophy, which occurs far from the cyst, is an emerging new complication of NCC. Evaluation of molecular pathways in brain regions close to and distant from the cyst could offer insight into this pathology.<h4>Methods</h4>Rats were inoculated intracranially with T. solium oncospheres. After 4 months, RNA was extracted from brain tissue samples in rats with NCC and uninfected controls, and cDNA was generated. Expression of 38 genes related to different molecular pathways involved in the inflammatory response and healing was assessed by RT-PCR array.<h4>Results</h4>Inflammatory cytokines IFN-γ, TNF-α, and IL-1, together witPLoS neglected tropical diseasesChanges in inflammatory gene expression in brain tissue adjacent and distant to a viable cyst in a rat model for neurocysticercosis.PMC81044105D43TW006581D43 TW006581U19 AI129909118‐2015‐FONDECYTU19AI129909 - TMRC programN-135 PNICP - PIAP 2015Sutherland GDelgado-Kamiche ADDavila-Villacorta DGCeliz RHCysticercosis Working Group in PeruVerastegui MRCarmen-Orozco RPGilman RHTrompeter GGavidia CGarcia HHfalseChanges in inflammatory gene expression in brain tissue adjacent and distant to a viable cyst in a rat model for neurocysticercosis.<h4>Background</h4>The parasite Taenia solium causes neurocysticercosis (NCC) in humans and is a common cause of adult-onset epilepsy in the developing world. Hippocampal atrophy, which occurs far from the cyst, is an emerging new complication of NCC. Evaluation of molecular pathways in brain regions close to and distant from the cyst could offer insight into this pathology.<h4>Methods</h4>Rats were inoculated intracranially with T. solium oncospheres. After 4 months, RNA was extracted from brain tissue samples in rats with NCC and uninfected controls, and cDNA was generated. Expression of 38 genes related to different molecular pathways involved in the inflammatory response and healing was assessed by RT-PCR array.<h4>Results</h4>Inflammatory cytokines IFN-γ, TNF-α, and IL-1, together wit2021-01-01T00:00:00Z2021 Apr2025-04-05T16:17:46.977Z2022-02-10T10:27:20.414ZS-EPMC81044103390541910.1371/journal.pntd.0009295