biostudies-literatureSadasivam PNIBIB NIH HHSNCATS NIH HHSNIA NIH HHSNational Institute of Biomedical Imaging and BioengineeringNational Institute on Aging372-381https://www.ebi.ac.uk/biostudies/studies/S-EPMC8105262biostudies-literatureUnknown23(3)<h4>Purpose</h4>Synapse loss is a hallmark of Alzheimer's disease (AD) and correlates with cognitive decline. The validation of a noninvasive in vivo imaging approach to quantify synapse would greatly facilitate our understanding of AD pathogenesis and assist drug developments for AD. As animal models of neurodegenerative and neuropsychiatric disorders play a critical role in the drug discovery and development process, a robust, objective, and translational method for quantifying therapeutic drug efficacy in animal models will facilitate the drug development process. In this study, we tested the quantification reliability of the SV2A PET tracer, [¹⁸F]SynVesT-1, in a mouse model of AD (APP/PS1) and wild-type controls, and developed a simplified quantification method to facilitateMolecular imaging and biologyQuantification of SV2A Binding in Rodent Brain Using [¹⁸F]SynVesT-1 and PET Imaging.PMC8105262K01EB023312K01 EB023312R01 AG052560R01 AG034924R01 AG058773R01AG052560UL1 TR001863R01AG058773P30 AG066508Toyonaga TLee SHuang YSpurrier JCarson RECai ZSadasivam PZheng MQFang XTXu YStrittmatter SMfalseQuantification of SV2A Binding in Rodent Brain Using [¹⁸F]SynVesT-1 and PET Imaging.<h4>Purpose</h4>Synapse loss is a hallmark of Alzheimer's disease (AD) and correlates with cognitive decline. The validation of a noninvasive in vivo imaging approach to quantify synapse would greatly facilitate our understanding of AD pathogenesis and assist drug developments for AD. As animal models of neurodegenerative and neuropsychiatric disorders play a critical role in the drug discovery and development process, a robust, objective, and translational method for quantifying therapeutic drug efficacy in animal models will facilitate the drug development process. In this study, we tested the quantification reliability of the SV2A PET tracer, [¹⁸F]SynVesT-1, in a mouse model of AD (APP/PS1) and wild-type controls, and developed a simplified quantification method to facilitate2021-01-01T00:00:00Z2021 Jun2025-04-29T11:30:10.772Z2025-04-06T19:54:38.031ZS-EPMC81052623325804010.1007/s11307-020-01567-9