{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Francisco KR"],"funding":["NIA NIH HHS","Kortney Rose Foundation","National Institutes of Health","NIGMS NIH HHS","National Institute on Aging"],"pagination":["113399"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC8105289"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["218"],"pubmed_abstract":["The N-acylsulfonamide functional group is a feature of the pharmacophore of several biologically active molecules, including marketed drugs. Although this acidic moiety presents multiple points of attachments that could be exploited to introduce structural diversification, depending on the circumstances, the replacement of the functional group itself with a suitable surrogate, or bioisostere, may be desirable. A number of N-acylsulfonamide bioisosteres have been developed over the years that provide opportunities to modulate both structure and physicochemical properties of this important structural motif. To enable an assessment of the relative impact on physicochemical properties that these replacements may have compared to the N-acylsulfonamide group, we conducted a structure-property re"],"journal":["European journal of medicinal chemistry"],"pubmed_title":["Structure property relationships of N-acylsulfonamides and related bioisosteres."],"pmcid":["PMC8105289"],"funding_grant_id":["R35 GM131902","AG061173","U01 AG061173"],"pubmed_authors":["Varricchio C","Brancale A","Ballatore C","Paniak TJ","Francisco KR","Kozlowski MC"],"additional_accession":[]},"is_claimable":false,"name":"Structure property relationships of N-acylsulfonamides and related bioisosteres.","description":"The N-acylsulfonamide functional group is a feature of the pharmacophore of several biologically active molecules, including marketed drugs. Although this acidic moiety presents multiple points of attachments that could be exploited to introduce structural diversification, depending on the circumstances, the replacement of the functional group itself with a suitable surrogate, or bioisostere, may be desirable. A number of N-acylsulfonamide bioisosteres have been developed over the years that provide opportunities to modulate both structure and physicochemical properties of this important structural motif. To enable an assessment of the relative impact on physicochemical properties that these replacements may have compared to the N-acylsulfonamide group, we conducted a structure-property re","dates":{"release":"2021-01-01T00:00:00Z","publication":"2021 Jun","modification":"2025-04-29T11:28:58.873Z","creation":"2025-02-18T23:36:07.746Z"},"accession":"S-EPMC8105289","cross_references":{"pubmed":["33823393"],"doi":["10.1016/j.ejmech.2021.113399"]}}