{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Zarate SM"],"funding":["National Institute of Neurological Disorders and Stroke","NINDS NIH HHS","American Parkinson Disease Association"],"pagination":["710-726"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC8106636"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["157(3)"],"pubmed_abstract":["Apoptotic endoplasmic reticulum (ER) stress is a major mechanism for dopaminergic (DA) loss in Parkinson's disease (PD). We assessed if low doses of the partial α4β2 nicotinic acetylcholine receptor agonist, cytisine attenuates apoptotic ER stress and exerts neuroprotection in substantia nigra pars compacta (SNc) DA neurons. Alternate day intraperitoneal injections of 0.2 mg/kg cytisine were administered to female and male mice with 6-hydroxydopamine (6-OHDA) lesions in the dorsolateral striatum, which caused unilateral degeneration of SNc DA neurons. Cytisine attenuated 6-OHDA-induced PD-related behaviors in female, but not in male mice. We also found significant reductions in tyrosine hydroxylase (TH) loss within the lesioned SNc of female, but not male mice. In contrast to female mice, "],"journal":["Journal of neurochemistry"],"pubmed_title":["Cytisine is neuroprotective in female but not male 6-hydroxydopamine lesioned parkinsonian mice and acts in combination with 17-β-estradiol to inhibit apoptotic endoplasmic reticulum stress in dopaminergic neurons."],"pmcid":["PMC8106636"],"funding_grant_id":["R01 NS115809","R01NS115809‐01"],"pubmed_authors":["Cude B","Pandey G","Garcia JA","Bancroft EA","Chilukuri S","Salem NA","Srinivasan R","Zarate SM","Hook M","Storey S"],"additional_accession":[]},"is_claimable":false,"name":"Cytisine is neuroprotective in female but not male 6-hydroxydopamine lesioned parkinsonian mice and acts in combination with 17-β-estradiol to inhibit apoptotic endoplasmic reticulum stress in dopaminergic neurons.","description":"Apoptotic endoplasmic reticulum (ER) stress is a major mechanism for dopaminergic (DA) loss in Parkinson's disease (PD). We assessed if low doses of the partial α4β2 nicotinic acetylcholine receptor agonist, cytisine attenuates apoptotic ER stress and exerts neuroprotection in substantia nigra pars compacta (SNc) DA neurons. Alternate day intraperitoneal injections of 0.2 mg/kg cytisine were administered to female and male mice with 6-hydroxydopamine (6-OHDA) lesions in the dorsolateral striatum, which caused unilateral degeneration of SNc DA neurons. Cytisine attenuated 6-OHDA-induced PD-related behaviors in female, but not in male mice. We also found significant reductions in tyrosine hydroxylase (TH) loss within the lesioned SNc of female, but not male mice. In contrast to female mice, ","dates":{"release":"2021-01-01T00:00:00Z","publication":"2021 May","modification":"2025-04-04T10:17:55.811Z","creation":"2025-04-04T10:17:55.811Z"},"accession":"S-EPMC8106636","cross_references":{"pubmed":["33354763"],"doi":["10.1111/jnc.15282"]}}