{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Gauthier A"],"funding":["Agence Nationale de la Recherche"],"pagination":["1141-1150"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC8108418"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["8(5)"],"pubmed_abstract":["We compared Simoa<sup>TM</sup> and Ella<sup>TM</sup> immunoassays to assess serum neurofilament-light chain levels in 203 multiple sclerosis patients from the OFSEP HD study. There was a strong correlation (ρ = 0.86, p < 0.0001) between both platforms. The Ella<sup>TM</sup> instrument overestimated values by 17%, but as the data were linear (p = 0.57), it was possible to apply a correction factor to Ella<sup>TM</sup> results. As for Simoa<sup>TM</sup> , serum neurofilament-light chain levels measured by Ella<sup>TM</sup> were correlated with age and EDSS and were significantly higher in active multiple sclerosis, suggesting that these assays are equivalent and can be used in routine clinical practice."],"journal":["Annals of clinical and translational neurology"],"pubmed_title":["Comparison of Simoa<sup>TM</sup> and Ella<sup>TM</sup> to assess serum neurofilament-light chain in multiple sclerosis."],"pmcid":["PMC8108418"],"funding_grant_id":["ANR‐10‐COHO‐002"],"pubmed_authors":["Perret M","Castelnovo G","Debouverie M","Lebrun-Frenay C","Brocard G","Berger E","Gout O","Moreau T","Gauthier A","Casey R","De Seze J","OFSEP Investigators","Casez O","Clavelou P","Trouillet-Assant S","Vukusic S","Viel S","Laplaud DA","Zephir H","Laurent-Chabalier S","Edan G","Ruet A","Thouvenot E","Lombard C"],"additional_accession":[]},"is_claimable":false,"name":"Comparison of Simoa<sup>TM</sup> and Ella<sup>TM</sup> to assess serum neurofilament-light chain in multiple sclerosis.","description":"We compared Simoa<sup>TM</sup> and Ella<sup>TM</sup> immunoassays to assess serum neurofilament-light chain levels in 203 multiple sclerosis patients from the OFSEP HD study. There was a strong correlation (ρ = 0.86, p < 0.0001) between both platforms. The Ella<sup>TM</sup> instrument overestimated values by 17%, but as the data were linear (p = 0.57), it was possible to apply a correction factor to Ella<sup>TM</sup> results. As for Simoa<sup>TM</sup> , serum neurofilament-light chain levels measured by Ella<sup>TM</sup> were correlated with age and EDSS and were significantly higher in active multiple sclerosis, suggesting that these assays are equivalent and can be used in routine clinical practice.","dates":{"release":"2021-01-01T00:00:00Z","publication":"2021 May","modification":"2025-04-06T23:53:35.315Z","creation":"2025-04-04T14:55:25.659Z"},"accession":"S-EPMC8108418","cross_references":{"pubmed":["33830650"],"doi":["10.1002/acn3.51355"]}}