biostudies-literatureThomas PSNIDA NIH HHS88-94https://www.ebi.ac.uk/biostudies/studies/S-EPMC8108700biostudies-literatureUnknown31(3)<h4>Objective</h4>Prior research demonstrated that the δ-opioid receptor (OPRD1) rs678849 variant influences opioid use in African Americans treated with methadone. We examined whether this variant moderated cocaine and opioid use in our clinical cohort of methadone and disulfiram treated recipients.<h4>Methods</h4>Cocaine and opioid codependent patients were stabilized for 2 weeks on methadone and subsequently randomized into groups treated with either methadone + placebo (n = 37) or methadone + disulfiram (250 mg/day; n = 33) for 12 weeks.<h4>Results</h4>A drop in cocaine-positive urine was found in the OPRD1 CC genotype group compared to T-allele carrier patients treated with methadone + disulfiram (P < 0.0001), but not in the methadone + placebo group. No difference in opioid-positive Psychiatric geneticsThe OPRD1 rs678849 variant influences outcome of disulfiram treatment for cocaine dependency in methadone-maintained patients.PMC8108700P50 DA018197R01 DA015477R25 DA026120Thomas PSHarding MJYe ANielsen EMPatriquin MNielsen DAHamon SCSpellicy CJKosten TRfalseThe OPRD1 rs678849 variant influences outcome of disulfiram treatment for cocaine dependency in methadone-maintained patients.<h4>Objective</h4>Prior research demonstrated that the δ-opioid receptor (OPRD1) rs678849 variant influences opioid use in African Americans treated with methadone. We examined whether this variant moderated cocaine and opioid use in our clinical cohort of methadone and disulfiram treated recipients.<h4>Methods</h4>Cocaine and opioid codependent patients were stabilized for 2 weeks on methadone and subsequently randomized into groups treated with either methadone + placebo (n = 37) or methadone + disulfiram (250 mg/day; n = 33) for 12 weeks.<h4>Results</h4>A drop in cocaine-positive urine was found in the OPRD1 CC genotype group compared to T-allele carrier patients treated with methadone + disulfiram (P < 0.0001), but not in the methadone + placebo group. No difference in opioid-positive 2021-01-01T00:00:00Z2021 Jun2025-04-18T19:38:31.342Z2025-04-07T07:20:36.36ZS-EPMC81087003395312310.1097/ypg.000000000000027910.1097/YPG.0000000000000279