biostudies-literatureUnknown9Gunawan A<b>Background:</b> While it has been known that the development of chronic kidney disease (CKD) and age-related cognitive impairment involves several mediators, the evidence in clinical practice only reveals nitride oxide synthase (NOS) and klotho. However, the evidence for this topic is conflicted. The aim of this study was to assess the role of NOS and klotho single nucleotide polymorphisms (SNPs) in the pathogenesis of CKD and age-related cognitive impairment. <b>Methods:</b> We performed a meta-analysis during October to December 2019. Paper collection was performed in major scientific websites, and we extracted information of interest from each paper. Data were analyzed using a Z-test with either random or fixed effect model. <b>Results:</b> Our initial assessment identified <i>NOS3</F1000Research252https://www.ebi.ac.uk/biostudies/studies/S-EPMC8112466biostudies-literatureNitride oxide synthase 3 and klotho gene polymorphisms in the pathogenesis of chronic kidney disease and age-related cognitive impairment: a systematic review and meta-analysis.PMC8112466Kartini DAWinoto ESPurnamasari YMayasari EDIlmawan MMahendra AIKrisna PAGunawan ASoeatmadji DWFajar JKSaifillah ESWulandari DSDantara TWITamara FWicaksono RSfalseNitride oxide synthase 3 and klotho gene polymorphisms in the pathogenesis of chronic kidney disease and age-related cognitive impairment: a systematic review and meta-analysis.<b>Background:</b> While it has been known that the development of chronic kidney disease (CKD) and age-related cognitive impairment involves several mediators, the evidence in clinical practice only reveals nitride oxide synthase (NOS) and klotho. However, the evidence for this topic is conflicted. The aim of this study was to assess the role of NOS and klotho single nucleotide polymorphisms (SNPs) in the pathogenesis of CKD and age-related cognitive impairment. <b>Methods:</b> We performed a meta-analysis during October to December 2019. Paper collection was performed in major scientific websites, and we extracted information of interest from each paper. Data were analyzed using a Z-test with either random or fixed effect model. <b>Results:</b> Our initial assessment identified <i>NOS3</2020-01-01T00:00:00Z20202025-04-18T19:11:55.35Z2022-02-10T12:14:02.144ZS-EPMC81124663403590110.12688/f1000research.22989.2