{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Soler ZM"],"funding":["NIAID NIH HHS","NIDCD NIH HHS","National Institute on Deafness and Other Communication Disorders"],"pagination":["1732-1741.e1"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC8113080"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["147(5)"],"pubmed_abstract":["<h4>Background</h4>Although chronic rhinosinusitis (CRS) is considered the most treatable form of olfactory dysfunction, there has been relatively little clinical attention focused on assessing endotypes as they pertain to olfactory loss.<h4>Objectives</h4>The goal of this study was to explore inflammatory endotypes in CRS using an unsupervised cluster analysis of olfactory cleft (OC) biomarkers in a phenotype-free approach.<h4>Methods</h4>Patients with CRS were prospectively recruited and psychophysical olfactory testing, Questionnaire of Olfactory Dysfunction (QOD-NS), and bilateral OC endoscopy were obtained. Mucus was collected from the OC and evaluated for 26 biomarkers using principal component analysis. Cluster analysis was performed using only OC biomarkers and differences in olfac"],"journal":["The Journal of allergy and clinical immunology"],"pubmed_title":["Endotyping chronic rhinosinusitis based on olfactory cleft mucus biomarkers."],"pmcid":["PMC8113080"],"funding_grant_id":["K23 DC014747","R03 DC013651","R01 DC005805","R01 AI144364"],"pubmed_authors":["Ramakrishnan VR","Soler ZM","Bodner TE","Mace JC","Mattos JL","Alt JA","Mulligan JK","Smith TL","Schlosser RJ"],"additional_accession":[]},"is_claimable":false,"name":"Endotyping chronic rhinosinusitis based on olfactory cleft mucus biomarkers.","description":"<h4>Background</h4>Although chronic rhinosinusitis (CRS) is considered the most treatable form of olfactory dysfunction, there has been relatively little clinical attention focused on assessing endotypes as they pertain to olfactory loss.<h4>Objectives</h4>The goal of this study was to explore inflammatory endotypes in CRS using an unsupervised cluster analysis of olfactory cleft (OC) biomarkers in a phenotype-free approach.<h4>Methods</h4>Patients with CRS were prospectively recruited and psychophysical olfactory testing, Questionnaire of Olfactory Dysfunction (QOD-NS), and bilateral OC endoscopy were obtained. Mucus was collected from the OC and evaluated for 26 biomarkers using principal component analysis. Cluster analysis was performed using only OC biomarkers and differences in olfac","dates":{"release":"2021-01-01T00:00:00Z","publication":"2021 May","modification":"2026-05-31T07:14:21.816Z","creation":"2025-04-04T07:55:39.862Z"},"accession":"S-EPMC8113080","cross_references":{"pubmed":["33549569"],"doi":["10.1016/j.jaci.2021.01.021"]}}