{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Steidl E"],"funding":["Dr. Senckenberg foundation","Else Kröner-Fresenius-Stiftung"],"pagination":["1956-1965"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC8113145"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["48(6)"],"pubmed_abstract":["<h4>Purpose</h4>Perfusion-weighted MRI (PWI) and O-(2-[<sup>18</sup>F]fluoroethyl-)-l-tyrosine ([<sup>18</sup>F]FET) PET are both applied to discriminate tumor progression (TP) from treatment-related changes (TRC) in patients with suspected recurrent glioma. While the combination of both methods has been reported to improve the diagnostic accuracy, the performance of a sequential implementation has not been further investigated. Therefore, we retrospectively analyzed the diagnostic value of consecutive PWI and [<sup>18</sup>F]FET PET.<h4>Methods</h4>We evaluated 104 patients with WHO grade II-IV glioma and suspected TP on conventional MRI using PWI and dynamic [<sup>18</sup>F]FET PET. Leakage corrected maximum relative cerebral blood volumes (rCBV<sub>max</sub>) were obtained from dynamic "],"journal":["European journal of nuclear medicine and molecular imaging"],"pubmed_title":["Sequential implementation of DSC-MR perfusion and dynamic [<sup>18</sup>F]FET PET allows efficient differentiation of glioma progression from treatment-related changes."],"pmcid":["PMC8113145"],"funding_grant_id":["2014/SIN-02","Clinican-Scientist Stipend"],"pubmed_authors":["Shah NJ","Polomac N","Steinbach JP","Lohmann P","Filss CP","Mottaghy FM","Maurer GD","Filipski K","Steidl E","Hmeidan SA","Hattingen E","Langen KJ","Galldiks N","Keil F"],"additional_accession":[]},"is_claimable":false,"name":"Sequential implementation of DSC-MR perfusion and dynamic [<sup>18</sup>F]FET PET allows efficient differentiation of glioma progression from treatment-related changes.","description":"<h4>Purpose</h4>Perfusion-weighted MRI (PWI) and O-(2-[<sup>18</sup>F]fluoroethyl-)-l-tyrosine ([<sup>18</sup>F]FET) PET are both applied to discriminate tumor progression (TP) from treatment-related changes (TRC) in patients with suspected recurrent glioma. While the combination of both methods has been reported to improve the diagnostic accuracy, the performance of a sequential implementation has not been further investigated. Therefore, we retrospectively analyzed the diagnostic value of consecutive PWI and [<sup>18</sup>F]FET PET.<h4>Methods</h4>We evaluated 104 patients with WHO grade II-IV glioma and suspected TP on conventional MRI using PWI and dynamic [<sup>18</sup>F]FET PET. Leakage corrected maximum relative cerebral blood volumes (rCBV<sub>max</sub>) were obtained from dynamic ","dates":{"release":"2021-01-01T00:00:00Z","publication":"2021 Jun","modification":"2025-04-19T16:17:20.765Z","creation":"2025-04-19T16:17:20.765Z"},"accession":"S-EPMC8113145","cross_references":{"pubmed":["33241456"],"doi":["10.1007/s00259-020-05114-0"]}}