biostudies-literatureSteidl EDr. Senckenberg foundationElse Kröner-Fresenius-Stiftung1956-1965https://www.ebi.ac.uk/biostudies/studies/S-EPMC8113145biostudies-literatureUnknown48(6)<h4>Purpose</h4>Perfusion-weighted MRI (PWI) and O-(2-[¹⁸F]fluoroethyl-)-l-tyrosine ([¹⁸F]FET) PET are both applied to discriminate tumor progression (TP) from treatment-related changes (TRC) in patients with suspected recurrent glioma. While the combination of both methods has been reported to improve the diagnostic accuracy, the performance of a sequential implementation has not been further investigated. Therefore, we retrospectively analyzed the diagnostic value of consecutive PWI and [¹⁸F]FET PET.<h4>Methods</h4>We evaluated 104 patients with WHO grade II-IV glioma and suspected TP on conventional MRI using PWI and dynamic [¹⁸F]FET PET. Leakage corrected maximum relative cerebral blood volumes (rCBV_max) were obtained from dynamic European journal of nuclear medicine and molecular imagingSequential implementation of DSC-MR perfusion and dynamic [¹⁸F]FET PET allows efficient differentiation of glioma progression from treatment-related changes.PMC81131452014/SIN-02Clinican-Scientist StipendShah NJPolomac NSteinbach JPLohmann PFilss CPMottaghy FMMaurer GDFilipski KSteidl EHmeidan SAHattingen ELangen KJGalldiks NKeil FfalseSequential implementation of DSC-MR perfusion and dynamic [¹⁸F]FET PET allows efficient differentiation of glioma progression from treatment-related changes.<h4>Purpose</h4>Perfusion-weighted MRI (PWI) and O-(2-[¹⁸F]fluoroethyl-)-l-tyrosine ([¹⁸F]FET) PET are both applied to discriminate tumor progression (TP) from treatment-related changes (TRC) in patients with suspected recurrent glioma. While the combination of both methods has been reported to improve the diagnostic accuracy, the performance of a sequential implementation has not been further investigated. Therefore, we retrospectively analyzed the diagnostic value of consecutive PWI and [¹⁸F]FET PET.<h4>Methods</h4>We evaluated 104 patients with WHO grade II-IV glioma and suspected TP on conventional MRI using PWI and dynamic [¹⁸F]FET PET. Leakage corrected maximum relative cerebral blood volumes (rCBV_max) were obtained from dynamic 2021-01-01T00:00:00Z2021 Jun2025-04-19T16:17:20.765Z2025-04-19T16:17:20.765ZS-EPMC81131453324145610.1007/s00259-020-05114-0