{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Tuominen S"],"funding":["Turku University Foundation","Svenska Kulturfonden","Finnish Governmental Research Funding for Turku University Hospital"],"pagination":["1312-1326"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC8113193"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["48(5)"],"pubmed_abstract":["<h4>Background</h4>Many malignant tumours have increased TSPO expression, which has been related to a poor prognosis. TSPO-PET tracers have not comprehensively been evaluated in peripherally located tumours. This study aimed to evaluate whether N,N-diethyl-2-(2-(4-([<sup>18</sup>F]fluoro)phenyl)-5,7-dimethylpyrazolo[1,5-a]pyrimidin-3-yl)acetamide ([<sup>18</sup>F]F-DPA) can reflect radiotherapy (RT)-induced changes in TSPO activity in head and neck squamous cell carcinoma (HNSCC).<h4>Methods</h4>RT was used to induce inflammatory responses in HNSCC xenografts and cells. [<sup>18</sup>F]F-DPA uptake was measured in vivo in non-irradiated and irradiated tumours, followed by ex vivo biodistribution, autoradiography, and radiometabolite analysis. In vitro studies were performed in parental and"],"journal":["European journal of nuclear medicine and molecular imaging"],"pubmed_title":["Evaluation of [<sup>18</sup>F]F-DPA as a target for TSPO in head and neck cancer under normal conditions and after radiotherapy."],"pmcid":["PMC8113193"],"funding_grant_id":["260982","13142","139742"],"pubmed_authors":["Rajander J","Keller T","Loyttyniemi E","Sandholm J","Tuominen S","Petruk N","Tuomela J","Lopez-Picon F","Eichin D","Verhassel A","Gronroos TJ"],"additional_accession":[]},"is_claimable":false,"name":"Evaluation of [<sup>18</sup>F]F-DPA as a target for TSPO in head and neck cancer under normal conditions and after radiotherapy.","description":"<h4>Background</h4>Many malignant tumours have increased TSPO expression, which has been related to a poor prognosis. TSPO-PET tracers have not comprehensively been evaluated in peripherally located tumours. This study aimed to evaluate whether N,N-diethyl-2-(2-(4-([<sup>18</sup>F]fluoro)phenyl)-5,7-dimethylpyrazolo[1,5-a]pyrimidin-3-yl)acetamide ([<sup>18</sup>F]F-DPA) can reflect radiotherapy (RT)-induced changes in TSPO activity in head and neck squamous cell carcinoma (HNSCC).<h4>Methods</h4>RT was used to induce inflammatory responses in HNSCC xenografts and cells. [<sup>18</sup>F]F-DPA uptake was measured in vivo in non-irradiated and irradiated tumours, followed by ex vivo biodistribution, autoradiography, and radiometabolite analysis. In vitro studies were performed in parental and","dates":{"release":"2021-01-01T00:00:00Z","publication":"2021 May","modification":"2026-04-18T01:36:16.209Z","creation":"2022-02-10T10:21:17.367Z"},"accession":"S-EPMC8113193","cross_references":{"pubmed":["33340054"],"doi":["10.1007/s00259-020-05115-z"]}}