{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["6(1)"],"submitter":["Zhang J"],"pubmed_abstract":["Since the outbreak of coronavirus disease 2019 (COVID-19), it has become a global pandemic. The spike (S) protein of etiologic severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) specifically recognizes human angiotensin-converting enzyme 2 (hACE2) as its receptor, which is recently identified as an interferon (IFN)-stimulated gene. Here, we find that hACE2 exists on the surface of exosomes released by different cell types, and the expression of exosomal hACE2 is increased by IFNα/β treatment. In particular, exosomal hACE2 can specifically block the cell entry of SARS-CoV-2, subsequently inhibit the replication of SARS-CoV-2 in vitro and ex vivo. Our findings have indicated that IFN is able to upregulate a viral receptor on the exosomes which competitively block the virus entry, exhibiting a potential antiviral strategy."],"journal":["Signal transduction and targeted therapy"],"pagination":["189"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC8113286"],"repository":["biostudies-literature"],"pubmed_title":["The interferon-stimulated exosomal hACE2 potently inhibits SARS-CoV-2 replication through competitively blocking the virus entry."],"pmcid":["PMC8113286"],"pubmed_authors":["Huang F","Chen Q","Pan T","Zhang J","Chen J","Zhang H","Yu F","Wang G","Li R","Li Y","Wang Q","Lu G","Xia B","Song Z","Yuan Y"],"additional_accession":[]},"is_claimable":false,"name":"The interferon-stimulated exosomal hACE2 potently inhibits SARS-CoV-2 replication through competitively blocking the virus entry.","description":"Since the outbreak of coronavirus disease 2019 (COVID-19), it has become a global pandemic. The spike (S) protein of etiologic severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) specifically recognizes human angiotensin-converting enzyme 2 (hACE2) as its receptor, which is recently identified as an interferon (IFN)-stimulated gene. Here, we find that hACE2 exists on the surface of exosomes released by different cell types, and the expression of exosomal hACE2 is increased by IFNα/β treatment. In particular, exosomal hACE2 can specifically block the cell entry of SARS-CoV-2, subsequently inhibit the replication of SARS-CoV-2 in vitro and ex vivo. Our findings have indicated that IFN is able to upregulate a viral receptor on the exosomes which competitively block the virus entry, exhibiting a potential antiviral strategy.","dates":{"release":"2021-01-01T00:00:00Z","publication":"2021 May","modification":"2024-11-19T17:50:12.25Z","creation":"2022-02-10T10:22:16.326Z"},"accession":"S-EPMC8113286","cross_references":{"pubmed":["33980808"],"doi":["10.1038/s41392-021-00604-5"]}}