{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["15"],"submitter":["Gu J"],"funding":["National Institute of Neurological Disorders and Stroke"],"pubmed_abstract":["Parkinson's disease (PD) and dementia with Lewy body (DLB) are the most common synucleinopathies. <i>SNCA</i> gene is a major genetic risk factor for these diseases group, and dysregulation of its expression has been implicated in the genetic etiologies of several synucleinopathies. DNA methylation at CpG island (CGI) within <i>SNCA</i> intron 1 has been suggested as a regulatory mechanism of <i>SNCA</i> expression, and changes in methylation levels at this region were associated with PD and DLB. However, the role of DNA methylation in the regulation of <i>SNCA</i> expression in a cell-type specific manner and its contribution to the pathogenesis of PD and DLB remain poorly understood, and the data are conflicting. Here, we employed a bisulfite pyrosequencing technique to profile the DNA m"],"journal":["Frontiers in neuroscience"],"pagination":["652226"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC8113398"],"repository":["biostudies-literature"],"pubmed_title":["Cell-Type Specific Changes in DNA Methylation of <i>SNCA</i> Intron 1 in Synucleinopathy Brains."],"pmcid":["PMC8113398"],"pubmed_authors":["Kantor B","Chiba-Falek O","Murphy SK","Barrera J","Yun Y","Gu J","Beach TG","Woltjer RL","Serrano GE"],"additional_accession":[]},"is_claimable":false,"name":"Cell-Type Specific Changes in DNA Methylation of <i>SNCA</i> Intron 1 in Synucleinopathy Brains.","description":"Parkinson's disease (PD) and dementia with Lewy body (DLB) are the most common synucleinopathies. <i>SNCA</i> gene is a major genetic risk factor for these diseases group, and dysregulation of its expression has been implicated in the genetic etiologies of several synucleinopathies. DNA methylation at CpG island (CGI) within <i>SNCA</i> intron 1 has been suggested as a regulatory mechanism of <i>SNCA</i> expression, and changes in methylation levels at this region were associated with PD and DLB. However, the role of DNA methylation in the regulation of <i>SNCA</i> expression in a cell-type specific manner and its contribution to the pathogenesis of PD and DLB remain poorly understood, and the data are conflicting. Here, we employed a bisulfite pyrosequencing technique to profile the DNA m","dates":{"release":"2021-01-01T00:00:00Z","publication":"2021","modification":"2025-04-19T16:17:28.335Z","creation":"2025-04-19T16:17:28.335Z"},"accession":"S-EPMC8113398","cross_references":{"pubmed":["33994928"],"doi":["10.3389/fnins.2021.652226"]}}