{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["O'Malley G"],"funding":["NIDDK NIH HHS"],"pagination":["245-252"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC8114941"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["23(4)"],"pubmed_abstract":["<b><i>Background:</i></b> Data are limited on the need for and benefits of pump setting optimization with automated insulin delivery. We examined clinical management of a closed-loop control (CLC) system and its relationship to glycemic outcomes. <b><i>Materials and Methods:</i></b> We analyzed personal parameter adjustments in 168 participants in a 6-month multicenter trial of CLC with Control-IQ versus sensor-augmented pump (SAP) therapy. Preset parameters (BR = basal rates, CF = correction factors, CR = carbohydrate ratios) were optimized at randomization, 2 and 13 weeks, for safety issues, participant concerns, or initiation by participants' usual diabetes care team. Time in range (TIR 70-180 mg/dL) was compared in the week before and after parameter changes. <b><i>Results:</i></b> In "],"journal":["Diabetes technology & therapeutics"],"pubmed_title":["Clinical Management and Pump Parameter Adjustment of the Control-IQ Closed-Loop Control System: Results from a 6-Month, Multicenter, Randomized Clinical Trial."],"pmcid":["PMC8114941"],"funding_grant_id":["P30 DK036836","U24 DK123768"],"pubmed_authors":["McCrady-Spitzer S","Levy CJ","Patibandla N","Eggerman T","Slover R","Dadlani V","Isganaitis E","Flint E","Tabatabai I","Paulson JA","Calvo K","Simha V","Brown SA","Ambler-Osborn L","Levister C","Renard E","Keller J","Berget C","Pinsker JE","Andre C","Murphy C","Campos T","iDCL Trial Research Group","Emory E","Jost E","Jacobson T","Conshafter K","Kovatchev B","O'Malley G","Lam D","Kudva YC","Reznik Y","Anderson S","Kim K","Kollman DRC","Rossick-Solis A","Raghinaru D","Borgman S","Laffel L","Ekhlaspour L","Morris K","Towers L","Church MM","Salas E","Voelmle M","Mitchell H","Roethke L","Piper M","Alonso GT","Buckingham B","Lum J","Wakeman C","Messer LH","Breton M","Ogyaadu S","Passman S","Green N","Forlenza GP","Cobelli C","Lovett J","Oliveri M","Gondor-Fredrick L","Town M","Arreza-Rubin G","Wadwa RP","Reid C","Kumari K","Beck JLR"],"additional_accession":[]},"is_claimable":false,"name":"Clinical Management and Pump Parameter Adjustment of the Control-IQ Closed-Loop Control System: Results from a 6-Month, Multicenter, Randomized Clinical Trial.","description":"<b><i>Background:</i></b> Data are limited on the need for and benefits of pump setting optimization with automated insulin delivery. We examined clinical management of a closed-loop control (CLC) system and its relationship to glycemic outcomes. <b><i>Materials and Methods:</i></b> We analyzed personal parameter adjustments in 168 participants in a 6-month multicenter trial of CLC with Control-IQ versus sensor-augmented pump (SAP) therapy. Preset parameters (BR = basal rates, CF = correction factors, CR = carbohydrate ratios) were optimized at randomization, 2 and 13 weeks, for safety issues, participant concerns, or initiation by participants' usual diabetes care team. Time in range (TIR 70-180 mg/dL) was compared in the week before and after parameter changes. <b><i>Results:</i></b> In ","dates":{"release":"2021-01-01T00:00:00Z","publication":"2021 Apr","modification":"2025-04-04T23:03:10.336Z","creation":"2025-02-18T23:32:28.498Z"},"accession":"S-EPMC8114941","cross_references":{"pubmed":["33155824"],"doi":["10.1089/dia.2020.0472"]}}