{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Soder HE"],"funding":["U.S. Department of Health & Human Services | NIH | National Institute on Drug Abuse (NIDA)","\"la Caixa\" Foundation (Caixa Foundation)","NIDA NIH HHS","NIMH NIH HHS","U.S. Department of Health & Human Services | NIH | National Institute on Drug Abuse",""la Caixa" Foundation","U.S. Department of Health & Human Services | NIH | National Institute of Mental Health","U.S. Department of Health & Human Services | NIH | National Institute of Mental Health (NIMH)"],"pagination":["1078-1085"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC8115674"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["46(6)"],"pubmed_abstract":["Effort-related decision-making and reward learning are both dopamine-dependent, but preclinical research suggests they depend on different dopamine signaling dynamics. Therefore, the same dose of a dopaminergic medication could have differential effects on effort for reward vs. reward learning. However, no study has tested how effort and reward learning respond to the same dopaminergic medication within subjects. The current study aimed to test the effect of therapeutic doses of d-amphetamine on effort for reward and reward learning in the same healthy volunteers. Participants (n = 30) completed the Effort Expenditure for Reward Task (EEfRT) measure of effort-related decision-making, and the Probabilistic Reward Task (PRT) measure of reward learning, under placebo and two doses of d-amphet"],"journal":["Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology"],"pubmed_title":["Dose-response effects of d-amphetamine on effort-based decision-making and reinforcement learning."],"pmcid":["PMC8115674"],"funding_grant_id":["R01 MH108605","F32MH115692","R01MH108605","K08 DA040006","LCF/BQ/DI19/11730047","R00 MH102355","F32 DA048542","F32 MH115692","F32DA048542","R00MH105305"],"pubmed_authors":["Lopez-Gamundi P","Hoots JK","Soder HE","Nunez C","Lane SD","Cooper JA","Treadway MT","Lawlor VM","Wardle MC"],"additional_accession":[]},"is_claimable":false,"name":"Dose-response effects of d-amphetamine on effort-based decision-making and reinforcement learning.","description":"Effort-related decision-making and reward learning are both dopamine-dependent, but preclinical research suggests they depend on different dopamine signaling dynamics. Therefore, the same dose of a dopaminergic medication could have differential effects on effort for reward vs. reward learning. However, no study has tested how effort and reward learning respond to the same dopaminergic medication within subjects. The current study aimed to test the effect of therapeutic doses of d-amphetamine on effort for reward and reward learning in the same healthy volunteers. Participants (n = 30) completed the Effort Expenditure for Reward Task (EEfRT) measure of effort-related decision-making, and the Probabilistic Reward Task (PRT) measure of reward learning, under placebo and two doses of d-amphet","dates":{"release":"2021-01-01T00:00:00Z","publication":"2021 May","modification":"2025-04-05T10:03:38.097Z","creation":"2025-04-05T10:03:38.097Z"},"accession":"S-EPMC8115674","cross_references":{"pubmed":["32722661"],"doi":["10.1038/s41386-020-0779-8"]}}