biostudies-literatureUnknown12Han CThe development of liver fibrosis is closely related to the gut microbiota, and the "gut-liver axis" is the most important connection between the two. ethyl acetate extract of <i>Cichorium pumilum</i> Jacq (CGEA) is an herbal extract consisting mainly of sesquiterpenoids. The anti-inflammatory and hepatoprotective effects of CGEA have been reported, but the anti-fibrotic effects of CGEA via intestinal microbes and the "gut-liver axis" cycle have rarely been reported. In this study, we observed that CGEA not only directly attenuated inflammatory factor levels in inflamed mice, but also attenuated liver inflammation as well as liver fibrosis degeneration in rats with liver fibrosis caused by colitis. We observed <i>in vitro</i> that CGEA significantly promoted the growth of Bifidobacterium aFrontiers in pharmacology683613https://www.ebi.ac.uk/biostudies/studies/S-EPMC8117150biostudies-literature<i>Cichorium pumilum</i> Jacq Extract Inhibits LPS-Induced Inflammation via MAPK Signaling Pathway and Protects Rats From Hepatic Fibrosis Caused by Abnormalities in the Gut-Liver Axis.PMC8117150Yao JHou JLi CZou NZhang YGao YChen WHan CQin DYuan JWu Xfalse<i>Cichorium pumilum</i> Jacq Extract Inhibits LPS-Induced Inflammation via MAPK Signaling Pathway and Protects Rats From Hepatic Fibrosis Caused by Abnormalities in the Gut-Liver Axis.The development of liver fibrosis is closely related to the gut microbiota, and the "gut-liver axis" is the most important connection between the two. ethyl acetate extract of <i>Cichorium pumilum</i> Jacq (CGEA) is an herbal extract consisting mainly of sesquiterpenoids. The anti-inflammatory and hepatoprotective effects of CGEA have been reported, but the anti-fibrotic effects of CGEA via intestinal microbes and the "gut-liver axis" cycle have rarely been reported. In this study, we observed that CGEA not only directly attenuated inflammatory factor levels in inflamed mice, but also attenuated liver inflammation as well as liver fibrosis degeneration in rats with liver fibrosis caused by colitis. We observed <i>in vitro</i> that CGEA significantly promoted the growth of Bifidobacterium a2021-01-01T00:00:00Z20212025-04-04T14:35:02.926Z2022-02-10T10:30:31.047ZS-EPMC81171503399511210.3389/fphar.2021.683613