biostudies-literatureUnknown29(2)Gupta RK<h4>Background and purpose</h4>Neuroinflammatory molecules, including tumor necrosis factor-alpha, interleukin1-beta, lymphocyte function associated molecule-1, and intercellular cell adhesion molecule-1 contribute to the development of brain abscess. We hypothesized that the high fractional anisotropy (FA) in the brain abscess cavity reflects the upregulation of these neuroinflammatory molecules.<h4>Materials and methods</h4>Diffusion tensor imaging (DTI) was performed in 24 patients with brain abscess and Staphylococcus aureus-treated as well as nontreated Jurket cell lines (at 4 time points: 1, 24, 48, and 72 hours). Neuroinflammatory molecules were quantified from the brain abscess cavity aspirate of the patients as well as from the heat-killed S aureus-treated and nontreated cell lineAJNR. American journal of neuroradiology326-32https://www.ebi.ac.uk/biostudies/studies/S-EPMC8118972biostudies-literatureIn vivo demonstration of neuroinflammatory molecule expression in brain abscess with diffusion tensor imaging.PMC8118972Gupta RKSrivastava CKhetan PTrivedi RPrasad ANarayana PANath KRathore RKPrasad KNHusain NHusain MfalseIn vivo demonstration of neuroinflammatory molecule expression in brain abscess with diffusion tensor imaging.<h4>Background and purpose</h4>Neuroinflammatory molecules, including tumor necrosis factor-alpha, interleukin1-beta, lymphocyte function associated molecule-1, and intercellular cell adhesion molecule-1 contribute to the development of brain abscess. We hypothesized that the high fractional anisotropy (FA) in the brain abscess cavity reflects the upregulation of these neuroinflammatory molecules.<h4>Materials and methods</h4>Diffusion tensor imaging (DTI) was performed in 24 patients with brain abscess and Staphylococcus aureus-treated as well as nontreated Jurket cell lines (at 4 time points: 1, 24, 48, and 72 hours). Neuroinflammatory molecules were quantified from the brain abscess cavity aspirate of the patients as well as from the heat-killed S aureus-treated and nontreated cell line2008-01-01T00:00:00Z2008 Feb2025-04-26T07:21:58.302Z2022-02-10T10:01:50.403ZS-EPMC81189721798937210.3174/ajnr.A082610.3174/ajnr.a0826