biostudies-literatureUnknown12Chang WShaanxi Science and Technology AssociationC-terminal peptidase (Ctp) cleaves the C-terminal extension of the D1 precursor (pD1) to form mature D1. Among the three homologs CtpA, CtpB, and CtpC in photosynthetic organisms only the first is capable of processing pD1 while the roles of CtpB and CtpC remain elusive. Phylogenetic analysis of Ctps from photosynthetic organisms revealed that CtpA has diverged early from CtpB and CtpC during evolution implying distinct roles for the Ctps. Analysis of Arabidopsis Ctp-deficient mutants revealed that pD1 processing was not affected in <i>atctpb</i>, <i>atctpc</i>, or <i>atctpbatctpc</i> mutants, demonstrating that AtCtpA, not AtCtpB or AtCtpC, is responsible for cleaving the pD1 C-terminal extension. Ectopic expression of <i>CtpAs</i> from <i>Synechococcus elongatus</i>, <i>Chlamydomonas reiFrontiers in plant science676036https://www.ebi.ac.uk/biostudies/studies/S-EPMC8121967biostudies-literatureDiverged Early From CtpB and CtpC, CtpA Has Evolved to Process D1 Precursor in Oxygenic Photosynthetic Organisms.PMC8121967Xu MLi CWang CFu WWang FSong HChang WLi WFu AShan YHuang TCui ZLuo YWang YChang HfalseDiverged Early From CtpB and CtpC, CtpA Has Evolved to Process D1 Precursor in Oxygenic Photosynthetic Organisms.C-terminal peptidase (Ctp) cleaves the C-terminal extension of the D1 precursor (pD1) to form mature D1. Among the three homologs CtpA, CtpB, and CtpC in photosynthetic organisms only the first is capable of processing pD1 while the roles of CtpB and CtpC remain elusive. Phylogenetic analysis of Ctps from photosynthetic organisms revealed that CtpA has diverged early from CtpB and CtpC during evolution implying distinct roles for the Ctps. Analysis of Arabidopsis Ctp-deficient mutants revealed that pD1 processing was not affected in <i>atctpb</i>, <i>atctpc</i>, or <i>atctpbatctpc</i> mutants, demonstrating that AtCtpA, not AtCtpB or AtCtpC, is responsible for cleaving the pD1 C-terminal extension. Ectopic expression of <i>CtpAs</i> from <i>Synechococcus elongatus</i>, <i>Chlamydomonas rei2021-01-01T00:00:00Z20212026-05-09T08:16:20.048Z2022-02-10T10:53:41.102ZS-EPMC81219673400211410.3389/fpls.2021.676036