biostudies-literatureCangiano MEuropean Commission Marie Skłodowska-Curie Innovative Training NetworkMedical Research CouncilCancer Foundation Finland sr2094https://www.ebi.ac.uk/biostudies/studies/S-EPMC8123677biostudies-literatureUnknown13(9)<h4>Background</h4>Prostate cancer (PCa) is the second most common tumour diagnosed in men. Tumoral heterogeneity in PCa creates a significant challenge to develop robust prognostic markers and novel targets for therapy. An analysis of gene regulatory networks (GRNs) in PCa may provide insight into progressive PCa. Herein, we exploited a graph-based enrichment score to integrate data from GRNs identified in preclinical prostate orthografts and differentially expressed genes in clinical resected PCa. We identified active regulons (transcriptional regulators and their targeted genes) associated with PCa recurrence following radical prostatectomy.<h4>Methods</h4>The expression of known transcription factors and co-factors was analysed in a panel of prostate orthografts (<i>n</i> = 18). We seaCancersGene Regulation Network Analysis on Human Prostate Orthografts Highlights a Potential Role for the &lt;i&gt;JMJD6&lt;/i&gt; Regulon in Clinical Prostate Cancer.PMC8123677721746210057MR/L017997/1Granchi ZBeumer IJJenster GHamilton GGrudniewska MNykter MUrbanucci AJanssen BCangiano MSalji MJLeung HYfalseGene Regulation Network Analysis on Human Prostate Orthografts Highlights a Potential Role for the &lt;i&gt;JMJD6&lt;/i&gt; Regulon in Clinical Prostate Cancer.<h4>Background</h4>Prostate cancer (PCa) is the second most common tumour diagnosed in men. Tumoral heterogeneity in PCa creates a significant challenge to develop robust prognostic markers and novel targets for therapy. An analysis of gene regulatory networks (GRNs) in PCa may provide insight into progressive PCa. Herein, we exploited a graph-based enrichment score to integrate data from GRNs identified in preclinical prostate orthografts and differentially expressed genes in clinical resected PCa. We identified active regulons (transcriptional regulators and their targeted genes) associated with PCa recurrence following radical prostatectomy.<h4>Methods</h4>The expression of known transcription factors and co-factors was analysed in a panel of prostate orthografts (<i>n</i> = 18). We sea2021-01-01T00:00:00Z2021 Apr2026-04-07T15:13:01.952Z2022-02-10T10:52:07.945ZS-EPMC81236773392599410.3390/cancers13092094