{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Fletcher P"],"funding":["National Institute of Environmental Health Sciences","NIEHS NIH HHS","National Institute of General Medical Sciences","NIGMS NIH HHS"],"pagination":["359-373"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC8127607"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["70(3)"],"pubmed_abstract":["<h4>Objective and design</h4>The omega-3 polyunsaturated fatty acid docosahexaenoic acid (DHA) has been reported to suppress inflammation. Pulmonary inflammation can be directly linked to exposure of various occupational and man-made particles leading to pulmonary diseases. Therapeutic treatments are lacking for particle-induced pulmonary inflammation. These studies evaluated DHA as a therapeutic treatment for semi-acute and chronic particle-induced pulmonary inflammation.<h4>Methods</h4>Balb/c mice were oropharyngeal instilled with hydrophobic multi-walled carbon nanotube (MWCNT) or hydrophilic crystalline silica (SiO<sub>2</sub>) either as one instillation (semi-acute) or once a week for 4 weeks (chronic). One week later, the mice were placed on either a control or 1% DHA-containing diet"],"journal":["Inflammation research : official journal of the European Histamine Research Society ... [et al.]"],"pubmed_title":["Therapeutic treatment of dietary docosahexaenoic acid for particle-induced pulmonary inflammation in Balb/c mice."],"pmcid":["PMC8127607"],"funding_grant_id":["R01 ES023209","R01 ES027353","F31 ES028100","P30 GM103338"],"pubmed_authors":["Fletcher P","Rhoderick JF","Postma B","Holian A","Pestka JJ","Buford M","Hamilton RF"],"additional_accession":[]},"is_claimable":false,"name":"Therapeutic treatment of dietary docosahexaenoic acid for particle-induced pulmonary inflammation in Balb/c mice.","description":"<h4>Objective and design</h4>The omega-3 polyunsaturated fatty acid docosahexaenoic acid (DHA) has been reported to suppress inflammation. Pulmonary inflammation can be directly linked to exposure of various occupational and man-made particles leading to pulmonary diseases. Therapeutic treatments are lacking for particle-induced pulmonary inflammation. These studies evaluated DHA as a therapeutic treatment for semi-acute and chronic particle-induced pulmonary inflammation.<h4>Methods</h4>Balb/c mice were oropharyngeal instilled with hydrophobic multi-walled carbon nanotube (MWCNT) or hydrophilic crystalline silica (SiO<sub>2</sub>) either as one instillation (semi-acute) or once a week for 4 weeks (chronic). One week later, the mice were placed on either a control or 1% DHA-containing diet","dates":{"release":"2021-01-01T00:00:00Z","publication":"2021 Mar","modification":"2025-04-04T10:16:18.895Z","creation":"2025-04-04T10:16:18.895Z"},"accession":"S-EPMC8127607","cross_references":{"pubmed":["33566171"],"doi":["10.1007/s00011-021-01443-4"]}}