biostudies-literatureFletcher PNational Institute of Environmental Health SciencesNIEHS NIH HHSNational Institute of General Medical SciencesNIGMS NIH HHS359-373https://www.ebi.ac.uk/biostudies/studies/S-EPMC8127607biostudies-literatureUnknown70(3)<h4>Objective and design</h4>The omega-3 polyunsaturated fatty acid docosahexaenoic acid (DHA) has been reported to suppress inflammation. Pulmonary inflammation can be directly linked to exposure of various occupational and man-made particles leading to pulmonary diseases. Therapeutic treatments are lacking for particle-induced pulmonary inflammation. These studies evaluated DHA as a therapeutic treatment for semi-acute and chronic particle-induced pulmonary inflammation.<h4>Methods</h4>Balb/c mice were oropharyngeal instilled with hydrophobic multi-walled carbon nanotube (MWCNT) or hydrophilic crystalline silica (SiO₂) either as one instillation (semi-acute) or once a week for 4 weeks (chronic). One week later, the mice were placed on either a control or 1% DHA-containing dietInflammation research : official journal of the European Histamine Research Society ... [et al.]Therapeutic treatment of dietary docosahexaenoic acid for particle-induced pulmonary inflammation in Balb/c mice.PMC8127607R01 ES023209R01 ES027353F31 ES028100P30 GM103338Fletcher PRhoderick JFPostma BHolian APestka JJBuford MHamilton RFfalseTherapeutic treatment of dietary docosahexaenoic acid for particle-induced pulmonary inflammation in Balb/c mice.<h4>Objective and design</h4>The omega-3 polyunsaturated fatty acid docosahexaenoic acid (DHA) has been reported to suppress inflammation. Pulmonary inflammation can be directly linked to exposure of various occupational and man-made particles leading to pulmonary diseases. Therapeutic treatments are lacking for particle-induced pulmonary inflammation. These studies evaluated DHA as a therapeutic treatment for semi-acute and chronic particle-induced pulmonary inflammation.<h4>Methods</h4>Balb/c mice were oropharyngeal instilled with hydrophobic multi-walled carbon nanotube (MWCNT) or hydrophilic crystalline silica (SiO₂) either as one instillation (semi-acute) or once a week for 4 weeks (chronic). One week later, the mice were placed on either a control or 1% DHA-containing diet2021-01-01T00:00:00Z2021 Mar2025-04-04T10:16:18.895Z2025-04-04T10:16:18.895ZS-EPMC81276073356617110.1007/s00011-021-01443-4