{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Clapier CR"],"funding":["Howard Hughes Medical Institute","NIGMS NIH HHS"],"pagination":["407-422"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC8127953"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["18(7)"],"pubmed_abstract":["Cells utilize diverse ATP-dependent nucleosome-remodelling complexes to carry out histone sliding, ejection or the incorporation of histone variants, suggesting that different mechanisms of action are used by the various chromatin-remodelling complex subfamilies. However, all chromatin-remodelling complex subfamilies contain an ATPase-translocase 'motor' that translocates DNA from a common location within the nucleosome. In this Review, we discuss (and illustrate with animations) an alternative, unifying mechanism of chromatin remodelling, which is based on the regulation of DNA translocation. We propose the 'hourglass' model of remodeller function, in which each remodeller subfamily utilizes diverse specialized proteins and protein domains to assist in nucleosome targeting or to different"],"journal":["Nature reviews. Molecular cell biology"],"pubmed_title":["Mechanisms of action and regulation of ATP-dependent chromatin-remodelling complexes."],"pmcid":["PMC8127953"],"funding_grant_id":["R01 GM060415","R01 GM054096","R01 GM049650","R35 GM122519"],"pubmed_authors":["Cairns BR","Clapier CR","Iwasa J","Peterson CL"],"additional_accession":[]},"is_claimable":false,"name":"Mechanisms of action and regulation of ATP-dependent chromatin-remodelling complexes.","description":"Cells utilize diverse ATP-dependent nucleosome-remodelling complexes to carry out histone sliding, ejection or the incorporation of histone variants, suggesting that different mechanisms of action are used by the various chromatin-remodelling complex subfamilies. However, all chromatin-remodelling complex subfamilies contain an ATPase-translocase 'motor' that translocates DNA from a common location within the nucleosome. In this Review, we discuss (and illustrate with animations) an alternative, unifying mechanism of chromatin remodelling, which is based on the regulation of DNA translocation. We propose the 'hourglass' model of remodeller function, in which each remodeller subfamily utilizes diverse specialized proteins and protein domains to assist in nucleosome targeting or to different","dates":{"release":"2017-01-01T00:00:00Z","publication":"2017 Jul","modification":"2025-04-20T02:43:01.884Z","creation":"2025-04-20T02:43:01.884Z"},"accession":"S-EPMC8127953","cross_references":{"pubmed":["28512350"],"doi":["10.1038/nrm.2017.26"]}}