{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Saunders U"],"funding":["NIDDK NIH HHS","NIAID NIH HHS"],"pagination":["1718-1729"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC8128940"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["105(8)"],"pubmed_abstract":["<h4>Background</h4>Human cytomegalovirus (CMV) infection is associated with renal allograft dysfunction and loss, particularly in combination with acute rejection. Emerging literature suggests that non-HLA antibodies may contribute to antibody-mediated rejection, but pathogen-induced antibodies have not been investigated in this context. This study examines the presence of CMV-induced antibodies in murine CMV (MCMV)-infected renal allografts during acute rejection.<h4>Methods</h4>Intragraft immunoglobulin G (IgG) and complement C3 immunostaining were compared among allogeneic MCMV D-/R-, D+/R-, and D+/R+ renal transplants. Intragraft antibody deposition was examined in B cell-deficient recipients treated with MCMV immune sera. Antibody binding and complement-dependent cytotoxicity (CDC) of"],"journal":["Transplantation"],"pubmed_title":["Murine Cytomegalovirus-induced Complement-fixing Antibodies Deposit in Murine Renal Allografts During Acute Rejection."],"pmcid":["PMC8128940"],"funding_grant_id":["R24 DK064400","R01 AI101138","P30 DK079337"],"pubmed_authors":["Saunders U","Kaptsan I","Zeng Q","Cianciolo R","Boddeda SR","Chen B","Li M","Velazquez V","Guo L","Ghere J","Schoeb TR","Dhital R","Maher S","Shimamura M"],"additional_accession":[]},"is_claimable":false,"name":"Murine Cytomegalovirus-induced Complement-fixing Antibodies Deposit in Murine Renal Allografts During Acute Rejection.","description":"<h4>Background</h4>Human cytomegalovirus (CMV) infection is associated with renal allograft dysfunction and loss, particularly in combination with acute rejection. Emerging literature suggests that non-HLA antibodies may contribute to antibody-mediated rejection, but pathogen-induced antibodies have not been investigated in this context. This study examines the presence of CMV-induced antibodies in murine CMV (MCMV)-infected renal allografts during acute rejection.<h4>Methods</h4>Intragraft immunoglobulin G (IgG) and complement C3 immunostaining were compared among allogeneic MCMV D-/R-, D+/R-, and D+/R+ renal transplants. Intragraft antibody deposition was examined in B cell-deficient recipients treated with MCMV immune sera. Antibody binding and complement-dependent cytotoxicity (CDC) of","dates":{"release":"2021-01-01T00:00:00Z","publication":"2021 Aug","modification":"2025-04-04T21:24:41.996Z","creation":"2025-04-04T21:24:41.996Z"},"accession":"S-EPMC8128940","cross_references":{"pubmed":["33214535"],"doi":["10.1097/TP.0000000000003548","10.1097/tp.0000000000003548"]}}