{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"submitter":["Thanh TT"],"funding":["Medical Research Council","Wellcome Trust"],"pubmed_abstract":["<h4>Objectives</h4>Central nervous system (CNS) infections are common causes of morbidity and mortality worldwide. We aimed to discover protein biomarkers that could rapidly and accurately identify the likely cause of the infections, essential for clinical management and improving outcome.<h4>Methods</h4>We applied liquid chromatography tandem mass spectrometry on 45 cerebrospinal fluid (CSF) samples from a cohort of adults with and without CNS infections to discover potential diagnostic biomarkers. We then validated the diagnostic performance of a selected biomarker candidate in an independent cohort of 364 consecutively treated adults with CNS infections admitted to a referral hospital in Vietnam.<h4>Results</h4>In the discovery cohort, we identified lipocalin 2 (LCN2) as a potential bio"],"journal":["Clinical microbiology and infection : the official publication of the European Society of Clinical Microbiology and Infectious Diseases"],"pagination":["S1198-743X(20)30408-0"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC8128987"],"repository":["biostudies-literature"],"pubmed_title":["Value of lipocalin 2 as a potential biomarker for bacterial meningitis."],"pmcid":["PMC8128987"],"funding_grant_id":["204904/Z/16/Z","G0701885","106680/B/14/Z"],"pubmed_authors":["Thu DDA","Geskus R","Thuong NTT","Oanh PKN","Hang VTT","Ngoc VB","Hanh NHH","Nhu LNT","Thwaites G","Casals-Pascual C","Hong NTT","Thanh TT","Chau NVV","Ny NTH","Ngoc NM","Chau LTM","Quynh VX","Fischer R","Hoa NT","Tan LV","Kessler BM","Hanh BTB","Diem LT","Phu NH","Nghia HDT","Duc DT","Uyen PN"],"additional_accession":[]},"is_claimable":false,"name":"Value of lipocalin 2 as a potential biomarker for bacterial meningitis.","description":"<h4>Objectives</h4>Central nervous system (CNS) infections are common causes of morbidity and mortality worldwide. We aimed to discover protein biomarkers that could rapidly and accurately identify the likely cause of the infections, essential for clinical management and improving outcome.<h4>Methods</h4>We applied liquid chromatography tandem mass spectrometry on 45 cerebrospinal fluid (CSF) samples from a cohort of adults with and without CNS infections to discover potential diagnostic biomarkers. We then validated the diagnostic performance of a selected biomarker candidate in an independent cohort of 364 consecutively treated adults with CNS infections admitted to a referral hospital in Vietnam.<h4>Results</h4>In the discovery cohort, we identified lipocalin 2 (LCN2) as a potential bio","dates":{"release":"2020-01-01T00:00:00Z","publication":"2020 Jul","modification":"2026-05-08T15:57:11.772Z","creation":"2025-02-18T23:55:02.964Z"},"accession":"S-EPMC8128987","cross_references":{"pubmed":["32659386"],"doi":["10.1016/j.cmi.2020.07.006"]}}