{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Zhao J"],"funding":["BLRD VA","NIAID NIH HHS","U.S. Department of Defense","Division of Intramural Research, National Institute of Allergy and Infectious Diseases","NIH HHS","Center for Integrated Healthcare, U.S. Department of Veterans Affairs"],"pagination":["658420"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC8129510"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["12"],"pubmed_abstract":["The hallmark of HIV/AIDS is a gradual depletion of CD4 T cells. Despite effective control by antiretroviral therapy (ART), a significant subgroup of people living with HIV (PLHIV) fails to achieve complete immune reconstitution, deemed as immune non-responders (INRs). The mechanisms underlying incomplete CD4 T cell recovery in PLHIV remain unclear. In this study, CD4 T cells from PLHIV were phenotyped and functionally characterized, focusing on their mitochondrial functions. The results show that while total CD4 T cells are diminished, cycling cells are expanded in PLHIV, especially in INRs. HIV-INR CD4 T cells are more activated, displaying exhausted and senescent phenotypes with compromised mitochondrial functions. Transcriptional profiling and flow cytometry analysis showed remarkable r"],"journal":["Frontiers in immunology"],"pubmed_title":["Mitochondrial Functions Are Compromised in CD4 T Cells From ART-Controlled PLHIV."],"pmcid":["PMC8129510"],"funding_grant_id":["R15 AI143377","PR170067","S10 OD021572","I01 BX002670","R01 AI114748","1I01BX002670, 1I01BX004281","R21 AI138598","R21AI138598, R01AI114748, S10OD021572","I01 BX004281"],"pubmed_authors":["Nguyen LNT","Morrison ZD","Moorman JP","Zhang J","Lu Z","Cao D","Khanal S","Thakuri BKC","Wang L","Ogbu SC","Liu Y","Gazzar ME","Ning S","Li Z","Nguyen LN","Yao ZQ","Wu XY","Zhao J","Dang X","Schank M"],"additional_accession":[]},"is_claimable":false,"name":"Mitochondrial Functions Are Compromised in CD4 T Cells From ART-Controlled PLHIV.","description":"The hallmark of HIV/AIDS is a gradual depletion of CD4 T cells. Despite effective control by antiretroviral therapy (ART), a significant subgroup of people living with HIV (PLHIV) fails to achieve complete immune reconstitution, deemed as immune non-responders (INRs). The mechanisms underlying incomplete CD4 T cell recovery in PLHIV remain unclear. In this study, CD4 T cells from PLHIV were phenotyped and functionally characterized, focusing on their mitochondrial functions. The results show that while total CD4 T cells are diminished, cycling cells are expanded in PLHIV, especially in INRs. HIV-INR CD4 T cells are more activated, displaying exhausted and senescent phenotypes with compromised mitochondrial functions. Transcriptional profiling and flow cytometry analysis showed remarkable r","dates":{"release":"2021-01-01T00:00:00Z","publication":"2021","modification":"2025-04-18T21:55:18.937Z","creation":"2025-04-07T09:41:14.837Z"},"accession":"S-EPMC8129510","cross_references":{"pubmed":["34017335"],"doi":["10.3389/fimmu.2021.658420"]}}