{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["19(5)"],"submitter":["Du D"],"pubmed_abstract":["Nucleotide-binding site-leucine-rich repeat (NB-LRR) resistance proteins are critical for plant resistance to pathogens; however, their mechanism of activation and signal transduction is still not well understood. We identified a mutation in an as yet uncharacterized rice coiled-coil (CC)-NB-LRR, Oryza sativa RPM1-like resistance gene 1 (OsRLR1), which leads to hypersensitive response (HR)-like lesions on the leaf blade and broad-range resistance to the fungal pathogen Pyricularia oryzae (syn. Magnaporthe oryzae) and the bacterial pathogen Xanthomonas oryzae pv. oryzae, together with strong growth reduction. Consistently, OsRLR1-overexpression lines showed enhanced resistance to both pathogens. Moreover, we found that OsRLR1 mediates the defence response through direct interaction in the n"],"journal":["Plant biotechnology journal"],"pagination":["1052-1064"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC8131040"],"repository":["biostudies-literature"],"pubmed_title":["The CC-NB-LRR OsRLR1 mediates rice disease resistance through interaction with OsWRKY19."],"pmcid":["PMC8131040"],"pubmed_authors":["Ling Y","Lu X","Liu M","Xing Y","Yun H","He G","Lefebvre B","Cai L","Zhang Q","Yang Z","Li Y","Sang X","Du D","Zhang Y","Chen X","Zhang C"],"additional_accession":[]},"is_claimable":false,"name":"The CC-NB-LRR OsRLR1 mediates rice disease resistance through interaction with OsWRKY19.","description":"Nucleotide-binding site-leucine-rich repeat (NB-LRR) resistance proteins are critical for plant resistance to pathogens; however, their mechanism of activation and signal transduction is still not well understood. We identified a mutation in an as yet uncharacterized rice coiled-coil (CC)-NB-LRR, Oryza sativa RPM1-like resistance gene 1 (OsRLR1), which leads to hypersensitive response (HR)-like lesions on the leaf blade and broad-range resistance to the fungal pathogen Pyricularia oryzae (syn. Magnaporthe oryzae) and the bacterial pathogen Xanthomonas oryzae pv. oryzae, together with strong growth reduction. Consistently, OsRLR1-overexpression lines showed enhanced resistance to both pathogens. Moreover, we found that OsRLR1 mediates the defence response through direct interaction in the n","dates":{"release":"2021-01-01T00:00:00Z","publication":"2021 May","modification":"2026-03-17T13:37:27.606Z","creation":"2025-04-07T03:05:47.266Z"},"accession":"S-EPMC8131040","cross_references":{"pubmed":["33368943"],"doi":["10.1111/pbi.13530"]}}