biostudies-literatureUnknown19(5)Du DNucleotide-binding site-leucine-rich repeat (NB-LRR) resistance proteins are critical for plant resistance to pathogens; however, their mechanism of activation and signal transduction is still not well understood. We identified a mutation in an as yet uncharacterized rice coiled-coil (CC)-NB-LRR, Oryza sativa RPM1-like resistance gene 1 (OsRLR1), which leads to hypersensitive response (HR)-like lesions on the leaf blade and broad-range resistance to the fungal pathogen Pyricularia oryzae (syn. Magnaporthe oryzae) and the bacterial pathogen Xanthomonas oryzae pv. oryzae, together with strong growth reduction. Consistently, OsRLR1-overexpression lines showed enhanced resistance to both pathogens. Moreover, we found that OsRLR1 mediates the defence response through direct interaction in the nPlant biotechnology journal1052-1064https://www.ebi.ac.uk/biostudies/studies/S-EPMC8131040biostudies-literatureThe CC-NB-LRR OsRLR1 mediates rice disease resistance through interaction with OsWRKY19.PMC8131040Ling YLu XLiu MXing YYun HHe GLefebvre BCai LZhang QYang ZLi YSang XDu DZhang YChen XZhang CfalseThe CC-NB-LRR OsRLR1 mediates rice disease resistance through interaction with OsWRKY19.Nucleotide-binding site-leucine-rich repeat (NB-LRR) resistance proteins are critical for plant resistance to pathogens; however, their mechanism of activation and signal transduction is still not well understood. We identified a mutation in an as yet uncharacterized rice coiled-coil (CC)-NB-LRR, Oryza sativa RPM1-like resistance gene 1 (OsRLR1), which leads to hypersensitive response (HR)-like lesions on the leaf blade and broad-range resistance to the fungal pathogen Pyricularia oryzae (syn. Magnaporthe oryzae) and the bacterial pathogen Xanthomonas oryzae pv. oryzae, together with strong growth reduction. Consistently, OsRLR1-overexpression lines showed enhanced resistance to both pathogens. Moreover, we found that OsRLR1 mediates the defence response through direct interaction in the n2021-01-01T00:00:00Z2021 May2026-03-17T13:37:27.606Z2025-04-07T03:05:47.266ZS-EPMC81310403336894310.1111/pbi.13530