{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["16(5)"],"submitter":["Helmer RA"],"funding":["The CH Foundation","Harry Weitlauf Endowment for Cancer Research"],"pubmed_abstract":["Methylation of the HLTF gene in colorectal cancer (CRC) cells occurs more frequently in men than women. Progressive epigenetic silencing of HLTF in tumor cells is accompanied by negligible expression in the tumor microenvironment (TME). Cell line-derived xenografts (CDX) were established in control (Hltf+/+) and Hltf-deleted male Rag2-/-IL2rg-/- mice by direct orthotopic cell microinjection (OCMI) of HLTF+/+HCT116 Red-FLuc cells into the submucosa of the cecum. Combinatorial induction of IL6 and S100A8/A9 in the Hltf-deleted TME with ICAM-1 and IL8 in the primary tumor activated a positive feedback loop. The proinflammatory niche produced a major shift in CDX metastasis to peritoneal dissemination compared to controls. Inducible nitric oxide (iNOS) gene expression and transactivation of th"],"journal":["PloS one"],"pagination":["e0251132"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC8133447"],"repository":["biostudies-literature"],"pubmed_title":["Helicase-like transcription factor-deletion from the tumor microenvironment in a cell line-derived xenograft model of colorectal cancer reprogrammed the human transcriptome-S-nitroso-proteome to promote inflammation and redirect metastasis."],"pmcid":["PMC8133447"],"pubmed_authors":["Kaur G","Chilton BS","Smith LA","Dufour JM","Helmer RA","Martinez-Zaguilan R"],"additional_accession":[]},"is_claimable":false,"name":"Helicase-like transcription factor-deletion from the tumor microenvironment in a cell line-derived xenograft model of colorectal cancer reprogrammed the human transcriptome-S-nitroso-proteome to promote inflammation and redirect metastasis.","description":"Methylation of the HLTF gene in colorectal cancer (CRC) cells occurs more frequently in men than women. Progressive epigenetic silencing of HLTF in tumor cells is accompanied by negligible expression in the tumor microenvironment (TME). Cell line-derived xenografts (CDX) were established in control (Hltf+/+) and Hltf-deleted male Rag2-/-IL2rg-/- mice by direct orthotopic cell microinjection (OCMI) of HLTF+/+HCT116 Red-FLuc cells into the submucosa of the cecum. Combinatorial induction of IL6 and S100A8/A9 in the Hltf-deleted TME with ICAM-1 and IL8 in the primary tumor activated a positive feedback loop. The proinflammatory niche produced a major shift in CDX metastasis to peritoneal dissemination compared to controls. Inducible nitric oxide (iNOS) gene expression and transactivation of th","dates":{"release":"2021-01-01T00:00:00Z","publication":"2021","modification":"2026-05-08T14:48:17.582Z","creation":"2022-02-10T12:15:34.037Z"},"accession":"S-EPMC8133447","cross_references":{"pubmed":["34010296"],"doi":["10.1371/journal.pone.0251132"]}}