{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Bao L"],"funding":["National Natural Science Foundation of China","National Natural Science Foundation of China (National Science Foundation of China)"],"pagination":["200"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC8134832"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["6(1)"],"pubmed_abstract":["Influenza A virus may circulate simultaneously with the SARS-CoV-2 virus, leading to more serious respiratory diseases during this winter. However, the influence of these viruses on disease outcome when both influenza A and SARS-CoV-2 are present in the host remains unclear. Using a mammalian model, sequential infection was performed in ferrets and in K18-hACE2 mice, with SARS-CoV-2 infection following H1N1. We found that co-infection with H1N1 and SARS-CoV-2 extended the duration of clinical manifestation of COVID-19, and enhanced pulmonary damage, but reduced viral shedding of throat swabs and viral loads in the lungs of ferrets. Moreover, mortality was increased in sequentially infected mice compared with single-infection mice. Compared with single-vaccine inoculation, co-inoculation of"],"journal":["Signal transduction and targeted therapy"],"pubmed_title":["Sequential infection with H1N1 and SARS-CoV-2 aggravated COVID-19 pathogenesis in a mammalian model, and co-vaccination as an effective method of prevention of COVID-19 and influenza."],"pmcid":["PMC8134832"],"funding_grant_id":["82041035"],"pubmed_authors":["Liu J","Gong S","Cong B","Liu M","Zhao B","Yu P","Li F","Wang G","Gao H","Bao L","Wei Q","Wang S","Qi F","Qu Y","Xue J","Deng W","Song Z","Lv Q","Xu Y","Qin C"],"additional_accession":[]},"is_claimable":false,"name":"Sequential infection with H1N1 and SARS-CoV-2 aggravated COVID-19 pathogenesis in a mammalian model, and co-vaccination as an effective method of prevention of COVID-19 and influenza.","description":"Influenza A virus may circulate simultaneously with the SARS-CoV-2 virus, leading to more serious respiratory diseases during this winter. However, the influence of these viruses on disease outcome when both influenza A and SARS-CoV-2 are present in the host remains unclear. Using a mammalian model, sequential infection was performed in ferrets and in K18-hACE2 mice, with SARS-CoV-2 infection following H1N1. We found that co-infection with H1N1 and SARS-CoV-2 extended the duration of clinical manifestation of COVID-19, and enhanced pulmonary damage, but reduced viral shedding of throat swabs and viral loads in the lungs of ferrets. Moreover, mortality was increased in sequentially infected mice compared with single-infection mice. Compared with single-vaccine inoculation, co-inoculation of","dates":{"release":"2021-01-01T00:00:00Z","publication":"2021 May","modification":"2025-04-05T10:29:03.594Z","creation":"2022-02-10T13:59:53.717Z"},"accession":"S-EPMC8134832","cross_references":{"pubmed":["34016949"],"doi":["10.1038/s41392-021-00618-z"]}}