{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Pinto G"],"funding":["Fundação para a Ciência e a Tecnologia"],"pagination":["366"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC8136144"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["22(1)"],"pubmed_abstract":["<h4>Background</h4>A total of 179 Shiga toxin-producing Escherichia coli (STEC) complete genomes were analyzed in terms of serotypes, prophage coding regions, and stx gene variants and their distribution. We further examined the genetic diversity of Stx-converting phage genomes (Stx phages), focusing on the lysis-lysogeny decision and lytic cassettes.<h4>Results</h4>We show that most STEC isolates belong to non-O157 serotypes (73 %), regardless the sources and geographical regions. While the majority of STEC genomes contain a single stx gene (61 %), strains containing two (35 %), three (3 %) and four (1 %) stx genes were also found, being stx2 the most prevalent gene variant. Their location is exclusively found in intact prophage regions, indicating that they are phage-borne. We further de"],"journal":["BMC genomics"],"pubmed_title":["Insights into the genome architecture and evolution of Shiga toxin encoding bacteriophages of Escherichia coli."],"pmcid":["PMC8136144"],"funding_grant_id":["SFRH/BD/117365/2016","PhageSTEC PTDC/CVT-CVT/29628/2017 [POCI-01-0145-FEDER-029628]","UIDB/04469/2020"],"pubmed_authors":["Almeida C","Sampaio M","Pinto G","Dias O","Oliveira H","Azeredo J"],"additional_accession":[]},"is_claimable":false,"name":"Insights into the genome architecture and evolution of Shiga toxin encoding bacteriophages of Escherichia coli.","description":"<h4>Background</h4>A total of 179 Shiga toxin-producing Escherichia coli (STEC) complete genomes were analyzed in terms of serotypes, prophage coding regions, and stx gene variants and their distribution. We further examined the genetic diversity of Stx-converting phage genomes (Stx phages), focusing on the lysis-lysogeny decision and lytic cassettes.<h4>Results</h4>We show that most STEC isolates belong to non-O157 serotypes (73 %), regardless the sources and geographical regions. While the majority of STEC genomes contain a single stx gene (61 %), strains containing two (35 %), three (3 %) and four (1 %) stx genes were also found, being stx2 the most prevalent gene variant. Their location is exclusively found in intact prophage regions, indicating that they are phage-borne. We further de","dates":{"release":"2021-01-01T00:00:00Z","publication":"2021 May","modification":"2025-04-18T14:54:15.539Z","creation":"2025-04-07T01:13:17.835Z"},"accession":"S-EPMC8136144","cross_references":{"pubmed":["34011288"],"doi":["10.1186/s12864-021-07685-0"]}}