{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Xu X"],"funding":["National Key Scientific Instrument and Equipment Development Projects of China","Guangxi Talent Highland of Preservation and Deep Processing Research in Fruit and Vegetables (CN)","Guangxi Talent Highland of Preservation and Deep Processing Research in Fruit and Vegetables","National Natural Science Foundation of China","National Key Scientific Instrument and Equipment Development Projects of China (CN)","Beijing Science and Technology Planning Project"],"pagination":["119"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC8140477"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["18(1)"],"pubmed_abstract":["<h4>Background</h4>Cerebral ischemia-reperfusion (I/R) injury is a major cause of early complications and unfavorable outcomes after endovascular thrombectomy (EVT) therapy in patients with acute ischemic stroke (AIS). Recent studies indicate that modulating microglia/macrophage polarization and subsequent inflammatory response may be a potential adjunct therapy to recanalization. Annexin A1 (ANXA1) exerts potent anti-inflammatory and pro-resolving properties in models of cerebral I/R injury. However, whether ANXA1 modulates post-I/R-induced microglia/macrophage polarization has not yet been fully elucidated.<h4>Methods</h4>We retrospectively collected blood samples from AIS patients who underwent successful recanalization by EVT and analyzed ANXA1 levels longitudinally before and after EV"],"journal":["Journal of neuroinflammation"],"pubmed_title":["Annexin A1 protects against cerebral ischemia-reperfusion injury by modulating microglia/macrophage polarization via FPR2/ALX-dependent AMPK-mTOR pathway."],"pmcid":["PMC8140477"],"funding_grant_id":["81671380","2016YFC1301703","D161100003816002","201920200501","81801231","82001317"],"pubmed_authors":["Jiao L","Hao J","Zhang J","Li F","Wang D","Yang B","Zhang M","Zhang L","Li L","Bai X","Wang J","Ren H","Wang T","Gao W","Xu X"],"additional_accession":[]},"is_claimable":false,"name":"Annexin A1 protects against cerebral ischemia-reperfusion injury by modulating microglia/macrophage polarization via FPR2/ALX-dependent AMPK-mTOR pathway.","description":"<h4>Background</h4>Cerebral ischemia-reperfusion (I/R) injury is a major cause of early complications and unfavorable outcomes after endovascular thrombectomy (EVT) therapy in patients with acute ischemic stroke (AIS). Recent studies indicate that modulating microglia/macrophage polarization and subsequent inflammatory response may be a potential adjunct therapy to recanalization. Annexin A1 (ANXA1) exerts potent anti-inflammatory and pro-resolving properties in models of cerebral I/R injury. However, whether ANXA1 modulates post-I/R-induced microglia/macrophage polarization has not yet been fully elucidated.<h4>Methods</h4>We retrospectively collected blood samples from AIS patients who underwent successful recanalization by EVT and analyzed ANXA1 levels longitudinally before and after EV","dates":{"release":"2021-01-01T00:00:00Z","publication":"2021 May","modification":"2025-04-04T20:17:53.305Z","creation":"2025-04-04T20:17:53.305Z"},"accession":"S-EPMC8140477","cross_references":{"pubmed":["34022892"],"doi":["10.1186/s12974-021-02174-3"]}}