biostudies-literatureXu XNational Key Scientific Instrument and Equipment Development Projects of ChinaGuangxi Talent Highland of Preservation and Deep Processing Research in Fruit and Vegetables (CN)Guangxi Talent Highland of Preservation and Deep Processing Research in Fruit and VegetablesNational Natural Science Foundation of ChinaNational Key Scientific Instrument and Equipment Development Projects of China (CN)Beijing Science and Technology Planning Project119https://www.ebi.ac.uk/biostudies/studies/S-EPMC8140477biostudies-literatureUnknown18(1)<h4>Background</h4>Cerebral ischemia-reperfusion (I/R) injury is a major cause of early complications and unfavorable outcomes after endovascular thrombectomy (EVT) therapy in patients with acute ischemic stroke (AIS). Recent studies indicate that modulating microglia/macrophage polarization and subsequent inflammatory response may be a potential adjunct therapy to recanalization. Annexin A1 (ANXA1) exerts potent anti-inflammatory and pro-resolving properties in models of cerebral I/R injury. However, whether ANXA1 modulates post-I/R-induced microglia/macrophage polarization has not yet been fully elucidated.<h4>Methods</h4>We retrospectively collected blood samples from AIS patients who underwent successful recanalization by EVT and analyzed ANXA1 levels longitudinally before and after EVJournal of neuroinflammationAnnexin A1 protects against cerebral ischemia-reperfusion injury by modulating microglia/macrophage polarization via FPR2/ALX-dependent AMPK-mTOR pathway.PMC8140477816713802016YFC1301703D1611000038160022019202005018180123182001317Jiao LHao JZhang JLi FWang DYang BZhang MZhang LLi LBai XWang JRen HWang TGao WXu XfalseAnnexin A1 protects against cerebral ischemia-reperfusion injury by modulating microglia/macrophage polarization via FPR2/ALX-dependent AMPK-mTOR pathway.<h4>Background</h4>Cerebral ischemia-reperfusion (I/R) injury is a major cause of early complications and unfavorable outcomes after endovascular thrombectomy (EVT) therapy in patients with acute ischemic stroke (AIS). Recent studies indicate that modulating microglia/macrophage polarization and subsequent inflammatory response may be a potential adjunct therapy to recanalization. Annexin A1 (ANXA1) exerts potent anti-inflammatory and pro-resolving properties in models of cerebral I/R injury. However, whether ANXA1 modulates post-I/R-induced microglia/macrophage polarization has not yet been fully elucidated.<h4>Methods</h4>We retrospectively collected blood samples from AIS patients who underwent successful recanalization by EVT and analyzed ANXA1 levels longitudinally before and after EV2021-01-01T00:00:00Z2021 May2025-04-04T20:17:53.305Z2025-04-04T20:17:53.305ZS-EPMC81404773402289210.1186/s12974-021-02174-3