{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Villa E"],"funding":["LAM Foundation","Tuberous Sclerosis Alliance","NHLBI NIH HHS","NCI NIH HHS","National Institutes of Health","NIGMS NIH HHS"],"pagination":["2076-2093.e9"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC8141029"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["81(10)"],"pubmed_abstract":["The mechanistic target of rapamycin complex 1 (mTORC1) regulates metabolism and cell growth in response to nutrient, growth, and oncogenic signals. We found that mTORC1 stimulates the synthesis of the major methyl donor, S-adenosylmethionine (SAM), through the control of methionine adenosyltransferase 2 alpha (MAT2A) expression. The transcription factor c-MYC, downstream of mTORC1, directly binds to intron 1 of MAT2A and promotes its expression. Furthermore, mTORC1 increases the protein abundance of Wilms' tumor 1-associating protein (WTAP), the positive regulatory subunit of the human N<sup>6</sup>-methyladenosine (m<sup>6</sup>A) RNA methyltransferase complex. Through the control of MAT2A and WTAP levels, mTORC1 signaling stimulates m<sup>6</sup>A RNA modification to promote protein synt"],"journal":["Molecular cell"],"pubmed_title":["mTORC1 stimulates cell growth through SAM synthesis and m<sup>6</sup>A mRNA-dependent control of protein synthesis."],"pmcid":["PMC8141029"],"funding_grant_id":["K08 HL128867","R00 CA194192","R01 HL149883","P30 CA060553","R01 GM135587","R01 GM143334","P01 CA120964"],"pubmed_authors":["Helmin KA","Gao P","Ben-Sahra I","Asara JM","Singer BD","Villa E","Sahu U","O'Hara BP","Ali ES"],"additional_accession":[]},"is_claimable":false,"name":"mTORC1 stimulates cell growth through SAM synthesis and m<sup>6</sup>A mRNA-dependent control of protein synthesis.","description":"The mechanistic target of rapamycin complex 1 (mTORC1) regulates metabolism and cell growth in response to nutrient, growth, and oncogenic signals. We found that mTORC1 stimulates the synthesis of the major methyl donor, S-adenosylmethionine (SAM), through the control of methionine adenosyltransferase 2 alpha (MAT2A) expression. The transcription factor c-MYC, downstream of mTORC1, directly binds to intron 1 of MAT2A and promotes its expression. Furthermore, mTORC1 increases the protein abundance of Wilms' tumor 1-associating protein (WTAP), the positive regulatory subunit of the human N<sup>6</sup>-methyladenosine (m<sup>6</sup>A) RNA methyltransferase complex. Through the control of MAT2A and WTAP levels, mTORC1 signaling stimulates m<sup>6</sup>A RNA modification to promote protein synt","dates":{"release":"2021-01-01T00:00:00Z","publication":"2021 May","modification":"2026-05-31T02:10:04.042Z","creation":"2025-02-18T23:32:20.945Z"},"accession":"S-EPMC8141029","cross_references":{"pubmed":["33756106"],"doi":["10.1016/j.molcel.2021.03.009"]}}