{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["9"],"submitter":["Wang MH"],"pubmed_abstract":["Sophisticated axolotl limb regeneration is a highly orchestrated process that requires highly regulated gene expression and epigenetic modification patterns at precise positions and timings. We previously demonstrated two waves of post-amputation expression of a nerve-mediated repressive epigenetic modulator, histone deacetylase 1 (HDAC1), at the wound healing (3 days post-amputation; 3 dpa) and blastema formation (8 dpa onward) stages in juvenile axolotls. Limb regeneration was profoundly inhibited by local injection of an HDAC inhibitor, MS-275, at the amputation sites. To explore the transcriptional response of post-amputation axolotl limb regeneration in a tissue-specific and time course-dependent manner after MS-275 treatment, we performed transcriptome sequencing of the epidermis and"],"journal":["Frontiers in cell and developmental biology"],"pagination":["641987"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC8143519"],"repository":["biostudies-literature"],"pubmed_title":["Timing Does Matter: Nerve-Mediated HDAC1 Paces the Temporal Expression of Morphogenic Genes During Axolotl Limb Regeneration."],"pmcid":["PMC8143519"],"pubmed_authors":["Lee HS","Chiou LL","Lin SP","Hsu CL","Wu CH","Wang MH","Tsai YT"],"additional_accession":[]},"is_claimable":false,"name":"Timing Does Matter: Nerve-Mediated HDAC1 Paces the Temporal Expression of Morphogenic Genes During Axolotl Limb Regeneration.","description":"Sophisticated axolotl limb regeneration is a highly orchestrated process that requires highly regulated gene expression and epigenetic modification patterns at precise positions and timings. We previously demonstrated two waves of post-amputation expression of a nerve-mediated repressive epigenetic modulator, histone deacetylase 1 (HDAC1), at the wound healing (3 days post-amputation; 3 dpa) and blastema formation (8 dpa onward) stages in juvenile axolotls. Limb regeneration was profoundly inhibited by local injection of an HDAC inhibitor, MS-275, at the amputation sites. To explore the transcriptional response of post-amputation axolotl limb regeneration in a tissue-specific and time course-dependent manner after MS-275 treatment, we performed transcriptome sequencing of the epidermis and","dates":{"release":"2021-01-01T00:00:00Z","publication":"2021","modification":"2026-05-10T03:27:20.419Z","creation":"2025-04-05T18:56:41.392Z"},"accession":"S-EPMC8143519","cross_references":{"pubmed":["34041236"],"doi":["10.3389/fcell.2021.641987"]}}