biostudies-literatureAmadou AWorld Cancer Research FundWorld Health OrganizationMedical Research CouncilNational Institute for Health Research (NIHR)1882-1890https://www.ebi.ac.uk/biostudies/studies/S-EPMC8144608biostudies-literatureUnknown124(11)<h4>Background</h4>We investigated whether associations between prevalent diabetes and cancer risk are pertinent to older adults and whether associations differ across subgroups of age, body weight status or levels of physical activity.<h4>Methods</h4>We harmonised data from seven prospective cohort studies of older individuals in Europe and the United States participating in the CHANCES consortium. Cox proportional hazard regression was used to estimate the associations of prevalent diabetes with cancer risk (all cancers combined, and for colorectum, prostate and breast). We calculated summary risk estimates across cohorts using pooled analysis and random-effects meta-analysis.<h4>Results</h4>A total of 667,916 individuals were included with an overall median (P25-P75) age at recruitment British journal of cancerPrevalent diabetes and risk of total, colorectal, prostate and breast cancers in an ageing population: meta-analysis of individual participant data from cohorts of the CHANCES consortium.PMC814460800112/211/82MR/K023241/1IIG_2019_1978G0601463Kee FJenab MWilsgaard TLiao LMMannisto SFreisling HVermeulen RCHVan Guelpen BTrichopoulou AQuiros JRTsilidis KKOrdonez-Mena JMSinha RSoderberg SSchottker BBoffetta PBrenner HAmadou ARomieu IMokoroa OKuulasmaa KfalsePrevalent diabetes and risk of total, colorectal, prostate and breast cancers in an ageing population: meta-analysis of individual participant data from cohorts of the CHANCES consortium.<h4>Background</h4>We investigated whether associations between prevalent diabetes and cancer risk are pertinent to older adults and whether associations differ across subgroups of age, body weight status or levels of physical activity.<h4>Methods</h4>We harmonised data from seven prospective cohort studies of older individuals in Europe and the United States participating in the CHANCES consortium. Cox proportional hazard regression was used to estimate the associations of prevalent diabetes with cancer risk (all cancers combined, and for colorectum, prostate and breast). We calculated summary risk estimates across cohorts using pooled analysis and random-effects meta-analysis.<h4>Results</h4>A total of 667,916 individuals were included with an overall median (P25-P75) age at recruitment 2021-01-01T00:00:00Z2021 May2026-07-16T12:01:41.004Z2025-04-05T11:08:09.703ZS-EPMC81446083377215210.1038/s41416-021-01347-4