{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["25(1)"],"submitter":["Wendel Garcia PD"],"funding":["CytoSorbents Europe GmbH","Union Bancaire Privée"],"pubmed_abstract":["<h4>Background</h4>Uncertainty about the optimal respiratory support strategies in critically ill COVID-19 patients is widespread. While the risks and benefits of noninvasive techniques versus early invasive mechanical ventilation (IMV) are intensely debated, actual evidence is lacking. We sought to assess the risks and benefits of different respiratory support strategies, employed in intensive care units during the first months of the COVID-19 pandemic on intubation and intensive care unit (ICU) mortality rates.<h4>Methods</h4>Subanalysis of a prospective, multinational registry of critically ill COVID-19 patients. Patients were subclassified into standard oxygen therapy ≥10 L/min (SOT), high-flow oxygen therapy (HFNC), noninvasive positive-pressure ventilation (NIV), and early IMV, accor"],"journal":["Critical care (London, England)"],"pagination":["175"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC8146172"],"repository":["biostudies-literature"],"pubmed_title":["Implications of early respiratory support strategies on disease progression in critical COVID-19: a matched subanalysis of the prospective RISC-19-ICU cohort."],"pmcid":["PMC8146172"],"pubmed_authors":["Montomoli J","Ince C","Stephan M","Mauri R","Ramelet AS","Wendel Garcia PD","Wu MA","Gommers D","Castro P","Apolo J","Klarer A","Jeitziner MM","Urech S","Welte T","Fumeaux T","Staudacher DL","Fabbri S","Salomon P","Lavanchy J","Shaikh K","Stahl K","Studhalter M","Naon D","Colombo R","Lozano-Gomez H","Hilty MP","Roche-Campo F","Jenni-Moser B","Siegemund M","Christ A","Redecker H","Grazioli S","Camen G","Filipovic M","Gamez-Zapata J","Aslanidis T","Potalivo A","Fleisch I","Laube M","Babik B","Hillermann T","Brem J","Meier J","Meyer Zu Bentrup F","Kleger GR","Hubner T","Rezoagli E","Magliocca A","Chau I","Jovic M","Locher P","Moret-Bochatay M","Brugger SD","Hillgaertner F","Zalba-Etayo B","Drvaric I","Wiegand J","Cereghetti S","Turrini F","Vitale G","Rilinger J","Zellweger N","Schott P","Alfaro-Farias M","Schuepbach RA","Boroli F","Lienhardt-Nobbe B","Ksouri H","Cogliati C","Fodor P","Marquardt K","Pugin J","Fogagnolo A","Ceriani R","Perez MH","Gerecke P","Margarit A","Sridharan GO","Spadaro S","Rodriguez-Garcia R","Neff T","Korsos A","Haberthuer C","Ensner R","Buehler PK","Rimensberger PC","Guerci P","Burkle C","Facondini F","Concha P","Vizmanos-Lamotte G","Escos-Orta J","Lander-Azcona A","Lambert A","Yuen B","Martinez A","Selz D","Petersen L","Jurkolow G","Tellez A","Delahaye G","Heise A","Laurent JC","Aguirre-Bermeo H","Franchitti Laurent M","Pietsch U","Mayor-Vazquez E","Sepulcri M","Gehring N","Merki L","Murrone M","David S","Simonini MS","Ceruti S","Wengenmayer T","Colak E","Novy E","Baltussen Weber A","Catena E","Taboada-Fraga X","Martin-Delgado MC","Ristic A","Dullenkopf A","Brenni M","Marrel J","Sieber M","Lussman RF","Heuberger DM","Losser MR","Gaspert T","RISC-19-ICU Investigators","Tschoellitsch T","Algaba-Calderon A","Michot MP"],"additional_accession":[]},"is_claimable":false,"name":"Implications of early respiratory support strategies on disease progression in critical COVID-19: a matched subanalysis of the prospective RISC-19-ICU cohort.","description":"<h4>Background</h4>Uncertainty about the optimal respiratory support strategies in critically ill COVID-19 patients is widespread. While the risks and benefits of noninvasive techniques versus early invasive mechanical ventilation (IMV) are intensely debated, actual evidence is lacking. We sought to assess the risks and benefits of different respiratory support strategies, employed in intensive care units during the first months of the COVID-19 pandemic on intubation and intensive care unit (ICU) mortality rates.<h4>Methods</h4>Subanalysis of a prospective, multinational registry of critically ill COVID-19 patients. Patients were subclassified into standard oxygen therapy ≥10 L/min (SOT), high-flow oxygen therapy (HFNC), noninvasive positive-pressure ventilation (NIV), and early IMV, accor","dates":{"release":"2021-01-01T00:00:00Z","publication":"2021 May","modification":"2026-05-08T17:45:38.643Z","creation":"2022-02-10T12:23:36.861Z"},"accession":"S-EPMC8146172","cross_references":{"pubmed":["34034782"],"doi":["10.1186/s13054-021-03580-y"]}}