{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Subiros-Funosas R"],"funding":["Cancer Research UK","European Research Council","Ministerio de Economía y Competitividad","Wellcome Trust","Departament d'Innovació, Universitats i Empresa, Generalitat de Catalunya","Engineering and Physical Sciences Research Council"],"pagination":["1368-1374"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC8148049"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["11(5)"],"pubmed_abstract":["Keratin 1 (KRT1) is overexpressed in squamous carcinomas and associated with aggressive pathologies in breast cancer. Herein we report the design and preparation of the first Trp-based red fluorogenic amino acid, which is synthetically accessible in a few steps and displays excellent photophysical properties, and its application in a minimally-disruptive labelling strategy to prepare a new fluorogenic cyclopeptide for imaging of KRT1+ cells in whole intact tumour tissues."],"journal":["Chemical science"],"pubmed_title":["Fluorogenic Trp(redBODIPY) cyclopeptide targeting keratin 1 for imaging of aggressive carcinomas."],"pmcid":["PMC8148049"],"funding_grant_id":["C49791/A17367","PIII-006","17367","2017 SGR 1439","ERA-NET PCIN-2015-224","771443","EP/M507258/1","CTQ2015-67870-P","716379","1783744"],"pubmed_authors":["Sintes M","Ma R","Vendrell M","Zhang CB","Ghashghaei O","Pappalardo M","Barth ND","Ho VCL","Barril X","Subiros-Funosas R","Lavilla R","Qian BZ","Mendive-Tapia L"],"additional_accession":[]},"is_claimable":false,"name":"Fluorogenic Trp(redBODIPY) cyclopeptide targeting keratin 1 for imaging of aggressive carcinomas.","description":"Keratin 1 (KRT1) is overexpressed in squamous carcinomas and associated with aggressive pathologies in breast cancer. Herein we report the design and preparation of the first Trp-based red fluorogenic amino acid, which is synthetically accessible in a few steps and displays excellent photophysical properties, and its application in a minimally-disruptive labelling strategy to prepare a new fluorogenic cyclopeptide for imaging of KRT1+ cells in whole intact tumour tissues.","dates":{"release":"2019-01-01T00:00:00Z","publication":"2019 Dec","modification":"2026-05-08T14:18:17.815Z","creation":"2022-02-10T14:38:09.35Z"},"accession":"S-EPMC8148049","cross_references":{"pubmed":["34123261"],"doi":["10.1039/c9sc05558d"]}}