biostudies-literatureUnknown49(5)Melchor-Lopez A<h4>Objectives</h4>We aimed to determine whether parameters associated with adipose tissue (adipocyte density and the circulating concentrations of markers of adipose tissue pathology) predict cardiovascular risk (CVR) modification after metabolic surgery (MS).<h4>Methods</h4>We performed a case-control study of patients with morbid obesity who were candidates for MS. CVR was defined using flow-mediated dilation (FMD) and carotid intima media thickness (CIMT), which were measured during the 9 months following MS. Subgroups of CVR reduction were defined using the following cut-offs: CIMT 10% and/or a two-fold increase in FMD.<h4>Results</h4>We studied 40 patients with morbid obesity (mean age 44.5 years, 75% women, mean body mass index 46.4 kg/m²) and high prevalences of the metaThe Journal of international medical research3000605211012569https://www.ebi.ac.uk/biostudies/studies/S-EPMC8150427biostudies-literatureIdentification of adipose tissue-related predictors of the reduction in cardiovascular risk induced by metabolic surgery.PMC8150427Salamanca-Garcia MGutierrez-Buendia JAPena-Sosa GGaytan-Fuentes OFVera-Gomez EAlcaraz-Estrada SLPineda-Juarez JAHernandez-Patricio AGarcia SPerez-Cabeza de Vaca RMondragon-Teran PTellez-Gonzalez MAZamora-Aleman CRBanderas-Lares DZSuarez-Cuenca JAContreras-Ramos AMontoya-Ramirez JRodriguez-Arellano MEMelchor-Lopez AEscamilla-Tilch MOrtiz-Fernandez MHernandez-Munoz REfalseIdentification of adipose tissue-related predictors of the reduction in cardiovascular risk induced by metabolic surgery.<h4>Objectives</h4>We aimed to determine whether parameters associated with adipose tissue (adipocyte density and the circulating concentrations of markers of adipose tissue pathology) predict cardiovascular risk (CVR) modification after metabolic surgery (MS).<h4>Methods</h4>We performed a case-control study of patients with morbid obesity who were candidates for MS. CVR was defined using flow-mediated dilation (FMD) and carotid intima media thickness (CIMT), which were measured during the 9 months following MS. Subgroups of CVR reduction were defined using the following cut-offs: CIMT 10% and/or a two-fold increase in FMD.<h4>Results</h4>We studied 40 patients with morbid obesity (mean age 44.5 years, 75% women, mean body mass index 46.4 kg/m²) and high prevalences of the meta2021-01-01T00:00:00Z2021 May2025-04-04T14:20:39.406Z2022-02-10T14:08:07.958ZS-EPMC81504273402418210.1177/03000605211012569