biostudies-literatureRandazzo DMDuke University Health System299-309https://www.ebi.ac.uk/biostudies/studies/S-EPMC8153806biostudies-literatureUnknown8(3)<h4>Background</h4>Spirituality can impact patients' attitudes and decisions about treatment and end-of-life care when coping with cancer. Previous studies documented health-related quality of life (HRQoL) and spiritual well-being (SWB) as positively correlated within a general cancer patient population, but little is known about their association in the primary brain tumor population. We sought to measure SWB in primary brain tumor patients and evaluate whether it was associated with HRQoL.<h4>Methods</h4>Six-hundred and six patients treated at The Preston Robert Tisch Brain Tumor Center at Duke between December 16, 2013 and February 28, 2014 with data in the PRoGREss registry are included in this retrospective analysis. Each patient completed the Functional Assessment of Chronic Illness Neuro-oncology practiceSpiritual well-being and its association with health-related quality of life in primary brain tumor patients.PMC8153806eIRB Pro00053653Affronti MLHealy PJackman JCrouch BDesjardins AMiller ESWoodring SMcSherry FPeters KBFriedman HSLipp ESRandazzo DMAshley DMHerndon JEfalseSpiritual well-being and its association with health-related quality of life in primary brain tumor patients.<h4>Background</h4>Spirituality can impact patients' attitudes and decisions about treatment and end-of-life care when coping with cancer. Previous studies documented health-related quality of life (HRQoL) and spiritual well-being (SWB) as positively correlated within a general cancer patient population, but little is known about their association in the primary brain tumor population. We sought to measure SWB in primary brain tumor patients and evaluate whether it was associated with HRQoL.<h4>Methods</h4>Six-hundred and six patients treated at The Preston Robert Tisch Brain Tumor Center at Duke between December 16, 2013 and February 28, 2014 with data in the PRoGREss registry are included in this retrospective analysis. Each patient completed the Functional Assessment of Chronic Illness 2021-01-01T00:00:00Z2021 Jun2025-04-05T10:04:13.143Z2025-04-05T10:04:13.143ZS-EPMC81538063405537710.1093/nop/npaa084