{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Plantz MA"],"funding":["National Institute of Arthritis and Musculoskeletal and Skin Diseases","U.S. Department of Energy","Argonne National Laboratory","Office of Science","National Institutes of Health","NIAMS NIH HHS"],"pagination":["146-158"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC8154748"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["127"],"pubmed_abstract":["We recently developed a recombinant growth factor-free bone regenerative scaffold composed of stoichiometric hydroxyapatite (HA) ceramic particles and human demineralized bone matrix (DBM) particles (HA-DBM). Here, we performed the first pre-clinical comparative evaluation of HA-DBM relative to the industry standard and established positive control, recombinant human bone morphogenetic protein-2 (rhBMP-2), using a rat posterolateral spinal fusion model (PLF). Female Sprague-Dawley rats underwent bilateral L4-L5 PLF with implantation of the HA-DBM scaffold or rhBMP-2. Fusion was evaluated using radiography and blinded manual palpation, while biomechanical testing quantified the segmental flexion-extension range-of-motion (ROM) and stiffness of the fused segments at 8-weeks postoperatively. "],"journal":["Acta biomaterialia"],"pubmed_title":["Osteoinductivity and biomechanical assessment of a 3D printed demineralized bone matrix-ceramic composite in a rat spine fusion model."],"pmcid":["PMC8154748"],"funding_grant_id":["R01 AR069580","DE-AC02-06CH11357","R01AR069580"],"pubmed_authors":["Blank KR","Minardi S","Shah RN","Hallman M","Plantz MA","Yun C","Stock SR","Greene AC","Hsu WK","Lyons JG","Muriuki M","Jeong S","Yamaguchi JT","Havey RM","Ellenbogen DJ","Patwardhan AG","Hsu EL","Jakus AE"],"additional_accession":[]},"is_claimable":false,"name":"Osteoinductivity and biomechanical assessment of a 3D printed demineralized bone matrix-ceramic composite in a rat spine fusion model.","description":"We recently developed a recombinant growth factor-free bone regenerative scaffold composed of stoichiometric hydroxyapatite (HA) ceramic particles and human demineralized bone matrix (DBM) particles (HA-DBM). Here, we performed the first pre-clinical comparative evaluation of HA-DBM relative to the industry standard and established positive control, recombinant human bone morphogenetic protein-2 (rhBMP-2), using a rat posterolateral spinal fusion model (PLF). Female Sprague-Dawley rats underwent bilateral L4-L5 PLF with implantation of the HA-DBM scaffold or rhBMP-2. Fusion was evaluated using radiography and blinded manual palpation, while biomechanical testing quantified the segmental flexion-extension range-of-motion (ROM) and stiffness of the fused segments at 8-weeks postoperatively. ","dates":{"release":"2021-01-01T00:00:00Z","publication":"2021 Jun","modification":"2025-04-04T20:15:35.465Z","creation":"2025-04-04T20:15:35.465Z"},"accession":"S-EPMC8154748","cross_references":{"pubmed":["33831576"],"doi":["10.1016/j.actbio.2021.03.060"]}}