{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Waller V"],"funding":["Swiss National Science Foundation","Vontobel-Stiftung","Swiss Cancer Research Foundation"],"pagination":["676583"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC8155607"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["11"],"pubmed_abstract":["Besides cytotoxic DNA damage irradiation of tumor cells triggers multiple intra- and intercellular signaling processes, that are part of a multilayered, treatment-induced stress response at the unicellular and tumor pathophysiological level. These processes are intertwined with intrinsic and acquired resistance mechanisms to the toxic effects of ionizing radiation and thereby co-determine the tumor response to radiotherapy. Proteolysis of structural elements and bioactive signaling moieties represents a major class of posttranslational modifications regulating intra- and intercellular communication. Plasma membrane-located and secreted metalloproteinases comprise a family of metal-, usually zinc-, dependent endopeptidases and sheddases with a broad variety of substrates including component"],"journal":["Frontiers in oncology"],"pubmed_title":["Combined Radiochemotherapy: Metalloproteinases Revisited."],"pmcid":["PMC8155607"],"funding_grant_id":["172885"],"pubmed_authors":["Waller V","Pruschy M"],"additional_accession":[]},"is_claimable":false,"name":"Combined Radiochemotherapy: Metalloproteinases Revisited.","description":"Besides cytotoxic DNA damage irradiation of tumor cells triggers multiple intra- and intercellular signaling processes, that are part of a multilayered, treatment-induced stress response at the unicellular and tumor pathophysiological level. These processes are intertwined with intrinsic and acquired resistance mechanisms to the toxic effects of ionizing radiation and thereby co-determine the tumor response to radiotherapy. Proteolysis of structural elements and bioactive signaling moieties represents a major class of posttranslational modifications regulating intra- and intercellular communication. Plasma membrane-located and secreted metalloproteinases comprise a family of metal-, usually zinc-, dependent endopeptidases and sheddases with a broad variety of substrates including component","dates":{"release":"2021-01-01T00:00:00Z","publication":"2021","modification":"2025-04-05T00:16:12.523Z","creation":"2022-02-10T13:20:30.355Z"},"accession":"S-EPMC8155607","cross_references":{"pubmed":["34055644"],"doi":["10.3389/fonc.2021.676583"]}}