biostudies-literatureWaller VSwiss National Science FoundationVontobel-StiftungSwiss Cancer Research Foundation676583https://www.ebi.ac.uk/biostudies/studies/S-EPMC8155607biostudies-literatureUnknown11Besides cytotoxic DNA damage irradiation of tumor cells triggers multiple intra- and intercellular signaling processes, that are part of a multilayered, treatment-induced stress response at the unicellular and tumor pathophysiological level. These processes are intertwined with intrinsic and acquired resistance mechanisms to the toxic effects of ionizing radiation and thereby co-determine the tumor response to radiotherapy. Proteolysis of structural elements and bioactive signaling moieties represents a major class of posttranslational modifications regulating intra- and intercellular communication. Plasma membrane-located and secreted metalloproteinases comprise a family of metal-, usually zinc-, dependent endopeptidases and sheddases with a broad variety of substrates including componentFrontiers in oncologyCombined Radiochemotherapy: Metalloproteinases Revisited.PMC8155607172885Waller VPruschy MfalseCombined Radiochemotherapy: Metalloproteinases Revisited.Besides cytotoxic DNA damage irradiation of tumor cells triggers multiple intra- and intercellular signaling processes, that are part of a multilayered, treatment-induced stress response at the unicellular and tumor pathophysiological level. These processes are intertwined with intrinsic and acquired resistance mechanisms to the toxic effects of ionizing radiation and thereby co-determine the tumor response to radiotherapy. Proteolysis of structural elements and bioactive signaling moieties represents a major class of posttranslational modifications regulating intra- and intercellular communication. Plasma membrane-located and secreted metalloproteinases comprise a family of metal-, usually zinc-, dependent endopeptidases and sheddases with a broad variety of substrates including component2021-01-01T00:00:00Z20212025-04-05T00:16:12.523Z2022-02-10T13:20:30.355ZS-EPMC81556073405564410.3389/fonc.2021.676583