{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["10(5)"],"submitter":["Dogan O"],"pubmed_abstract":["We proposed the hypothesis that high-risk clones of colistin-resistant K. pneumoniae (ColR-Kp) possesses a high number of virulence factors and has enhanced survival capacity against the neutrophil activity. We studied virulence genes of ColR-Kp isolates and neutrophil response in 142 patients with invasive ColR-Kp infections. The ST101 and ST395 ColR-Kp infections had higher 30-day mortality (58%, p = 0.005 and 75%, p = 0.003). The presence of yersiniabactin biosynthesis gene (ybtS) and ferric uptake operon associated gene (kfu) were significantly higher in ST101 (99%, p ≤ 0.001) and ST395 (94%, p < 0.012). Being in ICU (OR: 7.9; CI: 1.43-55.98; p = 0.024), kfu (OR:27.0; CI: 5.67-179.65; p < 0.001) and ST101 (OR: 17.2; CI: 2.45-350.40; p = 0.01) were found to be predictors of 30-day morta"],"journal":["Biology"],"pagination":["436"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC8155863"],"repository":["biostudies-literature"],"pubmed_title":["Virulence Determinants of Colistin-Resistant K. pneumoniae High-Risk Clones."],"pmcid":["PMC8155863"],"pubmed_authors":["Dogan O","Demiray A","Sahin OE","Ergonul O","Atac N","Kilicoglu BK","Can F","Karahuseyinoglu S","Gonen M","Vatansever C","Albayrak O"],"additional_accession":[]},"is_claimable":false,"name":"Virulence Determinants of Colistin-Resistant K. pneumoniae High-Risk Clones.","description":"We proposed the hypothesis that high-risk clones of colistin-resistant K. pneumoniae (ColR-Kp) possesses a high number of virulence factors and has enhanced survival capacity against the neutrophil activity. We studied virulence genes of ColR-Kp isolates and neutrophil response in 142 patients with invasive ColR-Kp infections. The ST101 and ST395 ColR-Kp infections had higher 30-day mortality (58%, p = 0.005 and 75%, p = 0.003). The presence of yersiniabactin biosynthesis gene (ybtS) and ferric uptake operon associated gene (kfu) were significantly higher in ST101 (99%, p ≤ 0.001) and ST395 (94%, p < 0.012). Being in ICU (OR: 7.9; CI: 1.43-55.98; p = 0.024), kfu (OR:27.0; CI: 5.67-179.65; p < 0.001) and ST101 (OR: 17.2; CI: 2.45-350.40; p = 0.01) were found to be predictors of 30-day morta","dates":{"release":"2021-01-01T00:00:00Z","publication":"2021 May","modification":"2025-04-18T16:06:33.584Z","creation":"2022-02-10T14:47:38.337Z"},"accession":"S-EPMC8155863","cross_references":{"pubmed":["34068937"],"doi":["10.3390/biology10050436"]}}