biostudies-literatureGuo LKey Technology Research and Development Program of ShandongNatural Science Foundation of Shandong ProvinceNational Natural Science Foundation of China2407-2413https://www.ebi.ac.uk/biostudies/studies/S-EPMC8157567biostudies-literatureUnknown11(9)In this study, a novel lanthanide-doped nanoprobe for monitoring dipicolinic acid (DPA), a unique biomarker of <i>Bacillus anthracis</i>, was constructed by coordination of Tb³⁺ with l-histidine (His) functionalized ZIF-8 (His@ZIF-8). After being functionalized with His, the resultant His@ZIF-8 had abundant carboxyl and amino groups, which like tongs help His@ZIF-8 "grasp" Tb³⁺ firmly to form a stable lanthanide-doped nanoparticle (His@ZIF-8/Tb³⁺). Owing to the unsaturated coordination of Tb³⁺ with the amino acid group, the resultant His@ZIF-8/Tb³⁺ showed reserved response sites of Tb³⁺ to DPA because of its unique molecular structure. After the His@ZIF-8/Tb³⁺ coordination with DPA, the intrinsic fluorescence emisChemical scienceThe role of l-histidine as molecular tongs: a strategy of grasping Tb³⁺ using ZIF-8 to design sensors for monitoring an anthrax biomarker on-the-spot.PMC8157567ZR2013BQ0192017GSF19109ZR2014BM029215050842147507421775089Guo LKong RXia LChen GLiang MWang XQu FfalseThe role of l-histidine as molecular tongs: a strategy of grasping Tb³⁺ using ZIF-8 to design sensors for monitoring an anthrax biomarker on-the-spot.In this study, a novel lanthanide-doped nanoprobe for monitoring dipicolinic acid (DPA), a unique biomarker of <i>Bacillus anthracis</i>, was constructed by coordination of Tb³⁺ with l-histidine (His) functionalized ZIF-8 (His@ZIF-8). After being functionalized with His, the resultant His@ZIF-8 had abundant carboxyl and amino groups, which like tongs help His@ZIF-8 "grasp" Tb³⁺ firmly to form a stable lanthanide-doped nanoparticle (His@ZIF-8/Tb³⁺). Owing to the unsaturated coordination of Tb³⁺ with the amino acid group, the resultant His@ZIF-8/Tb³⁺ showed reserved response sites of Tb³⁺ to DPA because of its unique molecular structure. After the His@ZIF-8/Tb³⁺ coordination with DPA, the intrinsic fluorescence emis2020-01-01T00:00:00Z2020 Jan2025-04-18T13:43:04.903Z2022-02-10T13:33:13.273ZS-EPMC81575673408440410.1039/d0sc00030b