{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Singh Y"],"funding":["German Research Foundation","German Federal Ministry of Health","Ferring Pharmaceuticals","Federal Ministry of Education and Research Bonn Office","The Francis Crick Institute","Else Kroner-Fresenius Foundation"],"pagination":["e07147"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC8159709"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["7(6)"],"pubmed_abstract":["The SARS-CoV-2 virus is the causative agent of the global COVID-19 infectious disease outbreak, which can lead to acute respiratory distress syndrome (ARDS). However, it is still unclear how the virus interferes with immune cell and metabolic functions in the human body. In this study, we investigated the immune response in acute or convalescent COVID-19 patients. We characterized the peripheral blood mononuclear cells (PBMCs) using flow cytometry and found that CD8<sup>+</sup> T cells were significantly subsided in moderate COVID-19 and convalescent patients. Furthermore, characterization of CD8<sup>+</sup> T cells suggested that convalescent patients have significantly diminished expression of both perforin and granzyme A. Using <sup>1</sup>H-NMR spectroscopy, we characterized the metabo"],"journal":["Heliyon"],"pubmed_title":["SARS-CoV-2 infection paralyzes cytotoxic and metabolic functions of the immune cells."],"pmcid":["PMC8159709"],"funding_grant_id":["10134"],"pubmed_authors":["Salker MS","Singh Y","Trautwein C","Bissinger R","Fendel R","Casadei N","Ossowski S","Berezhnoy G","Deutsche COVID-19 OMICS Initiate (DeCOI)","Riess O","Krickeberg N"],"additional_accession":[]},"is_claimable":false,"name":"SARS-CoV-2 infection paralyzes cytotoxic and metabolic functions of the immune cells.","description":"The SARS-CoV-2 virus is the causative agent of the global COVID-19 infectious disease outbreak, which can lead to acute respiratory distress syndrome (ARDS). However, it is still unclear how the virus interferes with immune cell and metabolic functions in the human body. In this study, we investigated the immune response in acute or convalescent COVID-19 patients. We characterized the peripheral blood mononuclear cells (PBMCs) using flow cytometry and found that CD8<sup>+</sup> T cells were significantly subsided in moderate COVID-19 and convalescent patients. Furthermore, characterization of CD8<sup>+</sup> T cells suggested that convalescent patients have significantly diminished expression of both perforin and granzyme A. Using <sup>1</sup>H-NMR spectroscopy, we characterized the metabo","dates":{"release":"2021-01-01T00:00:00Z","publication":"2021 Jun","modification":"2025-05-29T21:03:25.98Z","creation":"2022-02-11T09:41:02.159Z"},"accession":"S-EPMC8159709","cross_references":{"pubmed":["34075347"],"doi":["10.1016/j.heliyon.2021.e07147"]}}