{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["He S"],"funding":["Fundamental Research Funds for the Central Universities","National Natural Science Foundation of China"],"pagination":["8817-8827"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC8163376"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["11(33)"],"pubmed_abstract":["Carrying out the <i>in vivo</i> syntheses of drugs toxic to tumors based on the specific features of the tumor microenvironment is critical for ensuring specific antitumor efficacy. However, achieving <i>in situ</i> high-yield synthetic toxic drugs from non-toxic agents and reducing their drug resistance in hypoxic tumors remain challenges. Herein we created a tumor-microenvironment-responsive porous Pt/Pt(iv) methylene blue coordination polymer nanoshuttle (Pt/PtMBCPNS) photosensitizer with spatiotemporally controlled O<sub>2</sub> and singlet oxygen (<sup>1</sup>O<sub>2</sub>) self-sufficient for the <i>in vivo</i> high-yield synthesis of drugs and efficient hypoxic tumor therapy. After being endocytosed, the nanophotosensitizer as a cascade catalyst was observed to effectively catalyze "],"journal":["Chemical science"],"pubmed_title":["Spatiotemporally controlled O<sub>2</sub> and singlet oxygen self-sufficient nanophotosensitizers enable the <i>in vivo</i> high-yield synthesis of drugs and efficient hypoxic tumor therapy."],"pmcid":["PMC8163376"],"funding_grant_id":["lzujbky-2018-it03","21671088","21904052","21977041","21431002","lzujbky-2019-kb12","21876072"],"pubmed_authors":["Li J","Liu M","Wang B","Fu X","Chen F","Liu S","Zhang L","He S","Li T","Sun S","Lu S","Liang K","Hai J","Meng G"],"additional_accession":[]},"is_claimable":false,"name":"Spatiotemporally controlled O<sub>2</sub> and singlet oxygen self-sufficient nanophotosensitizers enable the <i>in vivo</i> high-yield synthesis of drugs and efficient hypoxic tumor therapy.","description":"Carrying out the <i>in vivo</i> syntheses of drugs toxic to tumors based on the specific features of the tumor microenvironment is critical for ensuring specific antitumor efficacy. However, achieving <i>in situ</i> high-yield synthetic toxic drugs from non-toxic agents and reducing their drug resistance in hypoxic tumors remain challenges. Herein we created a tumor-microenvironment-responsive porous Pt/Pt(iv) methylene blue coordination polymer nanoshuttle (Pt/PtMBCPNS) photosensitizer with spatiotemporally controlled O<sub>2</sub> and singlet oxygen (<sup>1</sup>O<sub>2</sub>) self-sufficient for the <i>in vivo</i> high-yield synthesis of drugs and efficient hypoxic tumor therapy. After being endocytosed, the nanophotosensitizer as a cascade catalyst was observed to effectively catalyze ","dates":{"release":"2020-01-01T00:00:00Z","publication":"2020 Jul","modification":"2025-04-05T10:31:07.099Z","creation":"2022-02-10T14:43:29.398Z"},"accession":"S-EPMC8163376","cross_references":{"pubmed":["34123135"],"doi":["10.1039/d0sc02387f"]}}