biostudies-literatureHe SFundamental Research Funds for the Central UniversitiesNational Natural Science Foundation of China8817-8827https://www.ebi.ac.uk/biostudies/studies/S-EPMC8163376biostudies-literatureUnknown11(33)Carrying out the <i>in vivo</i> syntheses of drugs toxic to tumors based on the specific features of the tumor microenvironment is critical for ensuring specific antitumor efficacy. However, achieving <i>in situ</i> high-yield synthetic toxic drugs from non-toxic agents and reducing their drug resistance in hypoxic tumors remain challenges. Herein we created a tumor-microenvironment-responsive porous Pt/Pt(iv) methylene blue coordination polymer nanoshuttle (Pt/PtMBCPNS) photosensitizer with spatiotemporally controlled O₂ and singlet oxygen (¹O₂) self-sufficient for the <i>in vivo</i> high-yield synthesis of drugs and efficient hypoxic tumor therapy. After being endocytosed, the nanophotosensitizer as a cascade catalyst was observed to effectively catalyze Chemical scienceSpatiotemporally controlled O₂ and singlet oxygen self-sufficient nanophotosensitizers enable the <i>in vivo</i> high-yield synthesis of drugs and efficient hypoxic tumor therapy.PMC8163376lzujbky-2018-it0321671088219040522197704121431002lzujbky-2019-kb1221876072Li JLiu MWang BFu XChen FLiu SZhang LHe SLi TSun SLu SLiang KHai JMeng GfalseSpatiotemporally controlled O₂ and singlet oxygen self-sufficient nanophotosensitizers enable the <i>in vivo</i> high-yield synthesis of drugs and efficient hypoxic tumor therapy.Carrying out the <i>in vivo</i> syntheses of drugs toxic to tumors based on the specific features of the tumor microenvironment is critical for ensuring specific antitumor efficacy. However, achieving <i>in situ</i> high-yield synthetic toxic drugs from non-toxic agents and reducing their drug resistance in hypoxic tumors remain challenges. Herein we created a tumor-microenvironment-responsive porous Pt/Pt(iv) methylene blue coordination polymer nanoshuttle (Pt/PtMBCPNS) photosensitizer with spatiotemporally controlled O₂ and singlet oxygen (¹O₂) self-sufficient for the <i>in vivo</i> high-yield synthesis of drugs and efficient hypoxic tumor therapy. After being endocytosed, the nanophotosensitizer as a cascade catalyst was observed to effectively catalyze 2020-01-01T00:00:00Z2020 Jul2025-04-05T10:31:07.099Z2022-02-10T14:43:29.398ZS-EPMC81633763412313510.1039/d0sc02387f