biostudies-literatureMao MNatural Science Foundation of Zhejiang ProvinceNational Natural Science Foundation of ChinaZhejiang Provincial Medical and Health Science and Technology Project845-858https://www.ebi.ac.uk/biostudies/studies/S-EPMC8164584biostudies-literatureUnknown99(6)Tamoxifen resistance remains the major obstacle to the estrogen receptor positive breast cancer endocrine therapy. Placenta-specific 8 (PLAC8) has been implicated in epithelial-mesenchymal transition and tumorigenesis. However, the molecular mechanisms underlying PLAC8 function in the context of tamoxifen resistance are unclear. Curcumin has attracted considerable attention in the last decades. It is isolated from Curcuma longa and has beneficial effects in cancer therapy. We studied this property by using MCF-7 and tamoxifen-resistant breast cancer cells (MCF-7/TAM) cell lines. PLAC8 can regulate MCF-7/TAM cell drug sensitivity through the MAPK/ERK pathway and shows the potential effects of curcumin or as a possible druggable target against tamoxifen failure.Journal of molecular medicine (Berlin, Germany)Regulation of tamoxifen sensitivity by the PLAC8/MAPK pathway axis is antagonized by curcumin-induced protein stability change.PMC8164584LY19H160292, LY19H160281, LY18H160005No. 81672729, No. 81602471, No. 81672840, No.81972597, No.819724532018RC048 2021RC016Mao MYang JHu DShen JTeng RZhang XChen YZhou JWang LfalseRegulation of tamoxifen sensitivity by the PLAC8/MAPK pathway axis is antagonized by curcumin-induced protein stability change.Tamoxifen resistance remains the major obstacle to the estrogen receptor positive breast cancer endocrine therapy. Placenta-specific 8 (PLAC8) has been implicated in epithelial-mesenchymal transition and tumorigenesis. However, the molecular mechanisms underlying PLAC8 function in the context of tamoxifen resistance are unclear. Curcumin has attracted considerable attention in the last decades. It is isolated from Curcuma longa and has beneficial effects in cancer therapy. We studied this property by using MCF-7 and tamoxifen-resistant breast cancer cells (MCF-7/TAM) cell lines. PLAC8 can regulate MCF-7/TAM cell drug sensitivity through the MAPK/ERK pathway and shows the potential effects of curcumin or as a possible druggable target against tamoxifen failure.2021-01-01T00:00:00Z2021 Jun2025-04-18T18:58:36.383Z2022-02-10T14:58:49.626ZS-EPMC81645843361165910.1007/s00109-021-02047-5